Results 61 to 70 of about 439,249 (297)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Comparing the Balance of Male Athletes Aged 11-14 Years With and Without Genu Varum

Biyumikānīk-i varzishī, 2019
Objective Maintaining balance is one of the most important functions of neuromuscular system in performing all simple and complex¬ sports activities. Musculoskeletal deformities especially, genu varum in the lower extremity, can negatively affect the ...
Reza Hosseini, Ali Asghar Norasteh, Nezam Nemati   +2 more
doaj  

Walk Longer! Using Wearable Inertial Sensors to Uncover Which Gait Aspects Should Be Treated to Increase Walking Endurance in People with Multiple Sclerosis

Sensors
Reduced walking endurance is common in people with multiple sclerosis (PwMS), leading to reduced social participation and increased fall risk. This highlights the importance of identifying which gait aspects should be mostly targeted by rehabilitation to
Ilaria Carpinella, Rita Bertoni, Denise Anastasi, Rebecca Cardini, Tiziana Lencioni, Maurizio Ferrarin, Davide Cattaneo, Elisa Gervasoni   +7 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Relationship between Core Stability Muscle Endurance and Static and Dynamic Balance in Basketball Players

Biyumikānīk-i varzishī, 2016
Objective: Balancing is the most basic function of the neuromuscular system in performing all simple and complex activities that contribute to health-related physical fitness. Core stability may be a contributing factor to static and dynamic balance. The
farzaneh saki, masumeh Baghban
doaj  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

A Novel MRI Compatible Balance Simulator to Detect Postural Instability in Parkinson's Disease

Frontiers in Neurology, 2019
Background: Postural instability is a debilitating and largely treatment-resistant symptom of Parkinson's disease (PD). A better understanding of the neural substrates contributing to postural instability could lead to new targets for improved ...
Elizabeth P. Pasman, Martin J. McKeown, Taylor W. Cleworth, Taylor W. Cleworth, Bastiaan R. Bloem, J. Timothy Inglis, J. Timothy Inglis, J. Timothy Inglis, Mark G. Carpenter, Mark G. Carpenter, Mark G. Carpenter   +10 more
doaj   +1 more source

Relationship between core muscle strength and dynamic balance among hospital staff [PDF]

, 2022
Nawaf Almutairi, Ahmad Alanazi, Mohamed K. Seyam, Faizan Kashoo, Danah Alyahya, Radhakrishnan Unnikrishnan   +5 more
openalex   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source