Results 71 to 80 of about 439,249 (297)

Investigation of Static and Dynamic Balance in School Basketball Players with a History of Ankle Injury

Biyumikānīk-i varzishī, 2020
Objective: This study aimed to investigate the static and dynamic balance in basketball students with an ankle injury history. Methods: Subjects of this study were 36 elementary school basketball male students who participated in this study purposefully ...
Ali Roshandel Hesari, Amin Roshandel Hesari   +1 more
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Effect of Active Video Game (Xbox Kinect) on Static and Dynamic Balance in Children with Autism Spectrum Disorders

مجله پژوهش در علوم توانبخشی, 2020
Introduction: Autism spectrum disorders are of neuro-developmental conditions with the most prevalence among the children during recent years. Children with autism spectrum disorders usually have mobility problems in balance.
Neda Ghobadi, Farhad Ghadiri, Rasoul Yaali, Ahmadreza Movahedi   +3 more
doaj   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

A Mechanical Descriptor of Instability in Human Locomotion: Experimental Findings in Control Subjects and People with Transfemoral Amputation

Applied Sciences, 2020
While multiple criteria to quantify gait instability exist, some limitations hinder their computation during realistic walking conditions. A descriptor, computed as the distance between the center of mass of the body and the minimal moment axis ( d ...
Nahime Al Abiad, Hélène Pillet, Bruno Watier   +2 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

An Interpretable Machine Learning Framework for Athlete Motor Profiling Using Multi-Domain Field Assessments: A Proof-of-Concept Study

Applied Sciences
Early detection of modifiable motor deficits is essential for safe, long-term athletic development, yet most field screens provide only binary risk scores.
Bartosz Wilczyński, Maciej Biały, Katarzyna Zorena   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Relationship between Dynamic Balance, Jumping Ability, and Agility with 100 m Sprinting Performance in Athletes with Intellectual Disabilities

Sports
Sprinting is a competitive event in athletics that requires a combination of speed, power, agility, and balance. This study investigated the relationship between dynamic balance, jumping ability, and agility with 100 m sprinting performance in athletes ...
Ghada Jouira, Dan Iulian Alexe, Dragoș Ioan Tohănean, Cristina Ioana Alexe, Răzvan Andrei Tomozei, Sonia Sahli   +5 more
doaj   +1 more source