Results 101 to 110 of about 1,275,522 (345)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Entrepreneurship, Dynamic Capabilities and New Firm Growth [PDF]

This paper applies the dynamic capability framework to the study of new firm growth. Using a longitudinal database of 354 firms over their first ten years, we provide an explanation of new firm growth in terms of new product development, R&D, inter-firm ...
F. Stam, Jennifer Telussa, Petra Gibcus
core  

Impact of Entrepreneurship on Innovation Performance of Chinese SMEs: Focusing on the Mediating Effect of Enterprise Dynamic Capability and Organizational Innovation Environment [PDF]

, 2022
Fang Cui, Jaehoon Song
openalex   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

How Dynamic Capabilities and Ambidextrous Learning Shape SME Innovation Performance: The Moderating Role of Exploratory and Exploitative Learning

Systems
This study examines the differential effects of three dimensions of dynamic capabilities on innovation performance and investigates how ambidextrous learning (exploratory and exploitative learning) moderates these relationships.
Yonghong Ma, Zihui Wei
doaj   +1 more source

Narcissistic CEOs, dynamic capability, and green innovation. [PDF]

Heliyon, 2023
Chang L, Liang R, Zhang J, Yan X, Tao H, Zhu T.   +5 more
europepmc   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Modeling the significance of dynamic capability on the performance of microfinance institutions. [PDF]

PLoS One, 2023
The HV, Yang M, Fazal SA, Maran, Gao J, Yang Q, Al Mamun A.   +6 more
europepmc   +1 more source

Deep Temporal-Recurrent-Replicated-Softmax for Topical Trends over Time

, 2018
Dynamic topic modeling facilitates the identification of topical trends over time in temporal collections of unstructured documents. We introduce a novel unsupervised neural dynamic topic model named as Recurrent Neural Network-Replicated Softmax Model ...
Andrassy, Bernt, Gupta, Pankaj, Rajaram, Subburam, Schütze, Hinrich   +3 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source