Results 171 to 180 of about 5,911,579 (291)
Multiscale Parcellation of Dynamic Causal Models of the Brain
Imaging NeuroscienceAbstract The hierarchical organization of the brain’s distributed network has received growing interest from the neuroscientific community, largely because of its potential to enhance our understanding of human cognition and behavior, in health and disease.
openaire +2 more sources
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Culture and gender modulate dlPFC integration in the emotional brain: evidence from dynamic causal modeling. [PDF]
Cogn Neurodyn, 2023 Pugh ZH +4 more
europepmc +1 more source
Restructing dynamic causal systems in equilibrium
, 2005 In this paper I consider general obstacles to the recovery of a causal system from its probability distribution. I argue that most of the well-known problems with this task belong in the class of what I call degenerate causal systems. I then consider the
Denver Dash
core
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
, 2010 A variety of questions in causal inference can be represented as probability distributions over hypothetical worlds where idealized randomized experiments known as interventions have taken place.
Tian, Jin, Shpitser, Ilya
core +1 more source
Dynamic causal modeling of evoked responses during emergency braking: an ERP study. [PDF]
Cogn Neurodyn, 2022 Sabahi Y, Setarehdan SK, Nasrabadi AM.
europepmc +1 more source
The multifaceted roles of lysosomes in cancer
Molecular Oncology, EarlyView.Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source