Results 121 to 130 of about 3,657,233 (310)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Dynamic characteristics of a space-station solar wing array [PDF]
A solar-wing-array concept is described which meets space-station requirements for minimum fundamental frequency (0.4 Hz), component modularity, and growth potential.
Bush, H. G., Dorsey, J. T.
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Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Nineteen sixty-seven behavioral model of man - His chains revealed [PDF]
Dynamic characteristics of physical-chemical systems in human behavior, and structural nature of ...
Iberall, A., Mc Culloch, W.
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Fluid Compressibility Effects on the Dynamic Response of Hydrostatic Journal Bearings [PDF]
, 1991 A theoretical analysis for the dynamic performance characteristics of laminar flow, capillar/orifice compensated hydrostatic journal bearings is presented. The analysis considers in detail the effect of fluid compressibility in the bearing recesses.
Sanandres, Luis A.
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Meitan xuebaoAiming at the problem that there exist lacks of analysis of the elastic properties of screen panel materials and research on the influence of mineral impact on the deflection changes of screen panel in response to the theory of large deflection ...
Sanpeng GONG +6 more
doaj +1 more source
Variable Dynamic Force Vector Rocket Test Apparatus [PDF]
Design and performance characteristics of variable dynamic force vector rocket test ...
Hudson, J. L., Jr. +2 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source