Results 101 to 110 of about 3,657,233 (310)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Advanced superposition methods for high speed turbopump vibration analysis [PDF]
The small, high pressure Mark 48 liquid hydrogen turbopump was analyzed and dynamically tested to determine the cause of high speed vibration at an operating speed of 92,400 rpm. This approaches the design point operating speed of 95,000 rpm. The initial
Campany, A. D., Nielson, C. E.
core +1 more source
New procedure for design of self-adaptive control systems [PDF]
, 1970 Adaptive control system compensates for changes in the dynamic characteristics of linear controlled elements.
Hofmann, L. G.
core +1 more source
Dynamic Stability Characteristics of Aircraft and Dynamics of Pilot
TRANSACTIONS OF THE JAPAN SOCIETY FOR AERONAUTICAL AND SPACE SCIENCES, 2002 Dynamics of pilot was studied quantitatively in relation to the change of dynamic stability characteristics of aircraft. Three pilot conducted bank control on flight simulator which simulate aircraft dynamics with large variety of dutch roll characteristics, and data was acquired.
Akio Kato, Hiroki Akiyoshi, Mitsuo Sato
openaire +3 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Dispersive dynamics in the characteristic moving frame [PDF]
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2019 A mechanism for dispersion to automatically arise from the dispersionless Whitham Modulation equations (WMEs) is presented, relying on the use of a moving frame. The speed of this is chosen to be one of the characteristics which emerge from the linearization of the Whitham system, and assuming these are real (and thus the WMEs are hyperbolic) morphs ...
openaire +4 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
LubricantsIn order to optimize sealing performance, a novel labyrinth seal with semi-elliptical teeth (SET) structure is proposed in this paper, which includes semi-elliptical teeth and a series of cavities.
Shebin Yan +4 more
doaj +1 more source
Role of circumferential flow in the stability of fluid-handling machine rotors [PDF]
The recent studies of the dynamic stiffness properties of fluid lubricated bearing and seals by the authors have yielded most of the generalized characteristics discussed and used in this paper.
Bently, D. E., Muszynska, A.
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source