Results 41 to 50 of about 45,946 (274)

A Reconfigurable Visual-Programming Library for Real-time Closed-loop Cellular Electrophysiology

open access: yesFrontiers in Neuroinformatics, 2015
Most of the software platforms for cellular electrophysiology are limited in terms of flexibility, hardware support, ease of use, or re-configuration and adaptation for non-expert users.
István eBiró   +3 more
doaj   +1 more source

Functional correlates of clinical phenotype and severity in recurrent SCN2A variants

open access: yesCommunications Biology, 2022
A comprehensive biophysical analysis of disease-associated mutations in the voltage-gated sodium channel gene, SCN2A, suggests that dynamic action potential clamp may be a better predictor than voltage clamp of how these mutations alter neuronal ...
Géza Berecki   +15 more
doaj   +1 more source

Design strategy of IGCT clamp circuit parameters based on bi-objective nonlinear optimization

open access: yesEnergy Reports, 2022
The integrated gate commutated thyristor (IGCT) is a high-power semiconductor device with excellent performance, whose operating characteristics are governed by the clamp circuit.
Tao Jiang, Xiaotao Han, Shaozhe Zhang
doaj   +1 more source

Establishment of an automated patch-clamp platform for electrophysiological and pharmacological evaluation of hiPSC-CMs

open access: yesStem Cell Research, 2019
Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have evolved into widely used and reliable cell sources for modeling cardiovascular channelopathies and for drug safety pharmacology.
Wener Li   +6 more
doaj   +1 more source

Weevil endosymbiont dynamics is associated with a clamping of immunity [PDF]

open access: yesBMC Genomics, 2015
Insects subsisting on nutritionally unbalanced diets have evolved long-term mutualistic relationships with intracellular symbiotic bacteria (endosymbionts). The endosymbiont population load undergoes changes along with insect development. In the cereal weevil Sitophilus oryzae, the midgut endosymbionts Sodalis pierantonius drastically multiply ...
Masson, F.   +9 more
openaire   +5 more sources

Statistics of neuronal identification with open and closed loop measures of intrinsic excitability

open access: yesFrontiers in Neural Circuits, 2012
In complex nervous systems patterns of neuronal activity and measures of intrinsic neuronal excitability are often used as criteria for identifying and/or classifying neurons.
Ted eBrookings   +2 more
doaj   +1 more source

Firing clamp: A novel method for single-trial estimation of excitatory and inhibitory synaptic neuronal conductances

open access: yesFrontiers in Cellular Neuroscience, 2014
Understanding non-stationary neuronal activity as seen in vivo requires estimation of both excitatory and inhibitory synaptic conductances from a single trial of recording.
Anton eChizhov   +5 more
doaj   +1 more source

An AFM-based stiffness clamp for dynamic control of rigidity. [PDF]

open access: yesPLoS ONE, 2011
Atomic force microscopy (AFM) has become a powerful tool for measuring material properties in biology and imposing mechanical boundary conditions on samples from single molecules to cells and tissues.
Kevin D Webster   +2 more
doaj   +1 more source

Stress in V-section band clamps

open access: yes, 2004
This paper presents an analysis of the stresses in V-section band clamps by examining the correlation between experimental work and theoretical models.
Shoghi, K.   +7 more
core   +1 more source

The pros and cons of degeneracy

open access: yeseLife, 2014
Drugs could treat neuropathic pain more effectively if they simultaneously targeted two or more types of ion channel.
Jean-Marc Goaillard, Martial A Dufour
doaj   +1 more source

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