Results 141 to 150 of about 477 (209)

Astrocytic FDX1 Contributes to Copper Dyshomeostasis‐associated Synaptic Dysfunction in Depression and Is Modulated by Exercise

Advanced Science, EarlyView.
Chronic stress disrupts copper homeostasis and promotes copper accumulation in the prelimbic cortex, leading to astrocytic FDX1 upregulation. Elevated astrocytic FDX1 impairs calcium signaling, induces structural atrophy, and disrupts synaptic function, contributing to depressive‐like behaviors. Physical exercise reverses these alterations by restoring
Lina Gao, Rongji Hui, Zhibo Tang, Tao Feng, Zhihang Hu, Xiaoqing Zhang, Ping Jiang, Hui Zhao, Kwok‐Fai So, Tianyuan Luo, Yanzhou Chang, Lan Yan   +11 more
wiley   +1 more source

Real‐Time Stress Visualization of Hydrogels Enabled by Supramolecularly Switched Stretch‐Induced Phase Separation

Advanced Science, EarlyView.
Supramolecular hydrogels enable real‐time visualization of mechanical stress through supramolecular switching mechanotransduction. Adamantane‐modified cellulose functions as a responsive domain that undergoes an on–off transition between hydrated and dehydrated states via reversible β‐cyclodextrin–adamantane complexation and decomplexation.
Sooyeon Noh, Akihide Sugawara, Naoaki Ishihara, Takashi Konishi, Yuki Ueda, Ryuhei Motokawa, Yoshinori Takashima, Hiroshi Uyama   +7 more
wiley   +1 more source

Rod Origami (RodOri) Spring Metamaterials for Tunable Vibration Control via Tailored Structural Instabilities

Advanced Science, EarlyView.
Rod Origami (RodOri) springs harness snap‐through instabilities of pre‐stressed curved rods with geometrically programmable buckling behavior. Integrating RodOri springs with distinct geometries yields multistable metamaterials that undergo stepwise reconfiguration via sequential snapping, achieving wide‐range tunability of stiffness and resonance ...
Jeseung Lee, Sophie Leanza, Ruike Renee Zhao   +2 more
wiley   +1 more source

Synergistic Effect of Gradient Conductivity and Gradient Microstructures Enabled Ultrasensitive and Ultrabroad Linear Flexible Tactile Sensors

Advanced Science, EarlyView.
A design of double gradient effect is proposed to resolve the contradictory optimization on sensitivity and linearity of piezoresistive tactile sensors. The ultrawide linearity is realized by the sequential trigger of pressure‐induced gradient conductivity‐enabled linear current owing to the gradient microstructures.
Yao Fang, Yiwei Wang, Bing Zheng, Liu Yang, Jingyi Yue, Qian Zhou, Jinrong Huang, Yongyun Mao, Qian Li, Jifei Wang, Dongsheng Tang, Yuxin Tang, Bingpu Zhou, Bing Ji   +13 more
wiley   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

Dynamic observer: ion channel measurement beyond voltage clamp

BMC Neuroscience, 2011
Nowotny Thomas, Drix Damien
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Exact Discrete Stochastic Simulation With Deep‐Learning‐Scale Gradient Optimization

Advanced Science, EarlyView.
A 203,796‐parameter gene regulatory network classifies handwritten digits with 98.4% accuracy using exact stochastic dynamics. The framework decouples forward simulation from backward differentiation, making continuous‐time Markov chain models compatible with deep‐learning optimization.
Jose M. G. Vilar, Leonor Saiz
wiley   +1 more source

An Anterior Cingulate Cortex‐Anterior Insular Cortex Glutamatergic Circuit Gates Stress‐Induced Visceral Hypersensitivity and Anxiety via Ionotropic Glutamate Receptors Trafficking

Advanced Science, EarlyView.
This study identifies an anterior cingulate cortex (ACC) to anterior insular cortex (AIC) glutamatergic (Glu) circuit that gates stress induced visceral hypersensitivity and anxiety. Circuit activation induces both phenotypes, whereas inhibition relieves them.
Junwen Wang, Guangbing Duan, Huihui Sun, Zhiyu Dong, Qiwei Wang, Xiaowei Li, Ying Chen, Shuchang Xu, Ying Huang   +8 more
wiley   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source