Results 21 to 30 of about 471 (209)

Pacemaker neuron and network oscillations depend on a neuromodulator-regulated linear current

Frontiers in Behavioral Neuroscience, 2010
Linear leak currents have been implicated in the regulation of neuronal excitability, generation of neuronal and network oscillations, and network state transitions.
Shunbing Zhao, Jorge P Golowasch, Jorge P Golowasch, Farzan Nadim, Farzan Nadim   +4 more
doaj   +1 more source

Preproteins couple the intrinsic dynamics of SecA to its ATPase cycle to translocate via a catch and release mechanism

Cell Reports, 2022
Summary: Protein machines undergo conformational motions to interact with and manipulate polymeric substrates. The Sec translocase promiscuously recognizes, becomes activated, and secretes >500 non-folded preprotein clients across bacterial cytoplasmic ...
Srinath Krishnamurthy, Marios-Frantzeskos Sardis, Nikolaos Eleftheriadis, Katerina E. Chatzi, Jochem H. Smit, Konstantina Karathanou, Giorgos Gouridis, Athina G. Portaliou, Ana-Nicoleta Bondar, Spyridoula Karamanou, Anastassios Economou   +10 more
doaj   +1 more source

Synchronisation through nonreciprocal connections in a hybrid hippocampus microcircuit

Frontiers in Neural Circuits, 2013
Synchronisation among neurons is thought to arise from the interplay between excitation and inhibition; however, the connectivity rules that contribute to synchronisation are still unknown.
Markus M Hilscher, Katarina E Leão, Richardson N Leão   +2 more
doaj   +1 more source

Dynamics of a clamped–clamped microbeam resonator considering fabrication imperfections [PDF]

Microsystem Technologies, 2014
We present an investigation into the static and dynamic behavior of an electrostatically actuated clamped---clamped polysilicon microbeam resonator accounting for its fabrication imperfections, which are commonly encountered in similar microstructures.
Bataineh, Ahmad M., Younis, Mohammad I.
openaire   +2 more sources

Ultrarapid Delayed Rectifier K+ Channelopathies in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Frontiers in Cell and Developmental Biology, 2020
Atrial fibrillation (AF) is the most common cardiac arrhythmia. About 5–15% of AF patients have a mutation in a cardiac gene, including mutations in KCNA5, encoding the Kv1.5 α-subunit of the ion channel carrying the atrial-specific ultrarapid delayed ...
Sarah Hilderink, Harsha D. Devalla, Leontien Bosch, Ronald Wilders, Arie O. Verkerk, Arie O. Verkerk   +5 more
doaj   +1 more source

A Hybrid Model for Safety Pharmacology on an Automated Patch Clamp Platform: Using Dynamic Clamp to Join iPSC-Derived Cardiomyocytes and Simulations of Ik1 Ion Channels in Real-Time

Frontiers in Physiology, 2018
An important aspect of the Comprehensive In Vitro Proarrhythmia Assay (CiPA) proposal is the use of human stem cell-derived cardiomyocytes and the confirmation of their predictive power in drug safety assays.
Birgit Goversen, Nadine Becker, Sonja Stoelzle-Feix, Alison Obergrussberger, Marc A. Vos, Toon A. B. van Veen, Niels Fertig, Teun P. de Boer   +7 more
doaj   +1 more source

Patch-clamp and multi-electrode array electrophysiological analysis in acute mouse brain slices

STAR Protocols, 2021
Summary: Patch-clamp and multi-electrode array electrophysiology techniques are used to measure dynamic functional properties of neurons. Whole-cell and cell-attached patch-clamp recordings in brain slices can be performed in voltage-clamp and current ...
Kevin M. Manz, Justin K. Siemann, Douglas G. McMahon, Brad A. Grueter   +3 more
doaj   +1 more source

The dendritic location of the L-type current and its deactivation by the somatic AHP current both contribute to firing bistability in motoneurons

Frontiers in Computational Neuroscience, 2014
Spinal motoneurons may display a variety of firing patterns including bistability between repetitive firing and quiescence and, more rarely, bistability between two firing states of different frequencies.
Marin eManuel, Daniel eZytnicki, Claude eMeunier   +2 more
doaj   +1 more source

A Reconfigurable Visual-Programming Library for Real-time Closed-loop Cellular Electrophysiology

Frontiers in Neuroinformatics, 2015
Most of the software platforms for cellular electrophysiology are limited in terms of flexibility, hardware support, ease of use, or re-configuration and adaptation for non-expert users.
István eBiró, Michele eGiugliano, Michele eGiugliano, Michele eGiugliano   +3 more
doaj   +1 more source

Functional correlates of clinical phenotype and severity in recurrent SCN2A variants

Communications Biology, 2022
A comprehensive biophysical analysis of disease-associated mutations in the voltage-gated sodium channel gene, SCN2A, suggests that dynamic action potential clamp may be a better predictor than voltage clamp of how these mutations alter neuronal ...
Géza Berecki, Katherine B. Howell, Jacqueline Heighway, Nelson Olivier, Jill Rodda, Isabella Overmars, Danique R. M. Vlaskamp, Tyson L. Ware, Simone Ardern-Holmes, Gaetan Lesca, Michael Alber, Pierangelo Veggiotti, Ingrid E. Scheffer, Samuel F. Berkovic, Markus Wolff, Steven Petrou   +15 more
doaj   +1 more source