Results 131 to 140 of about 3,165,419 (303)

Low‐Density Lipoprotein Receptor‐Targeted Biomimetic Nanoplatform Suppresses Glioblastoma Stemness and Remodels Antitumor Immunity via Dual Metabolic Disruption

Advanced Science, EarlyView.
A low‐density lipoprotein receptor‐oriented biomimetic nanoplatform couples brain‐tumor delivery with a mechanistically matched regorafenib‐erythrodiol combination. Concurrent disruption of autophagic nutrient salvage and cholesterol homeostasis collapses bioenergetic and signaling support, suppresses glioblastoma stemness, and promotes immunogenic ...
Yining Jiang, Wenzhuo Yang, Wenting Cheng, Jing Zuo, Lin Pan, Sheng Zhong, Ren Geng, Yao Zhao, Zijian Chen, Canhua Huang, Yang Bai, Liyan Zhao, Yunqian Li   +12 more
wiley   +1 more source

Digital Comparator in Excitable Chemical Media

, 2015
It is well established that spatial excitable media can be used for information processing. A single excitation pulse can represent one bit of information and a group of excitations forms a message.
Guo, Shan, Sun MZ(孙明竹), Zhao X(赵新), Han JD(韩建达)   +3 more
core  

Experimental research of vibrations of angle measurement comparator [PDF]

, 2012
The aim of the presented research was to determine calibration error caused by mechanical instability of angle measurement comparator system. Vibrations were measured at the significant points of the system and dynamic characteristics of the system were ...
Barakauskas, Algimantas, A. Kilikevicius, A. Barakauskas, V. Mokšin, Kasparaitis, Albinas, Mokšin, Vadim, Kilikevičius, Artūras, A. Kasparaitis   +7 more
core  

Sustainable Hydrogel‐Forming Microneedle‐Reservoir Patches for Transdermal Delivery of Hydrophilic Macromolecules: Biopolymers, Green Manufacturing and Translation

Advanced Science, EarlyView.
Hydrogel‐forming microneedle (HFMN)‐reservoir patches provide a modular route for controlled transdermal delivery of hydrophilic biomacromolecules. The platform integrates skin‐barrier penetration, sustainable biopolymers, scalable green manufacturing, hydration‐driven transport, model‐cargo validation, and translational quality requirements.
Siddharth Mohanty, Mehmet Onur Aydogdu, Sijia Kang, Xinbo Li, Mohan Edirisinghe   +4 more
wiley   +1 more source

Power-Efficient Cross-Coupled Pre-Amplifier Stage for Double-Tail Dynamic Comparators

IEEE Access
The growing demand for high-speed, high-resolution analog-to-digital converters (ADCs) in portable applications has driven the need for low-power design solutions of on-chip comparators that maintain comparable performance.
Hamed Aminzadeh, Abdolrasool Ghasemi, Gaetano Palumbo   +2 more
doaj   +1 more source

A Dual‐Functional Nanoplatform Targeting the dsDNA–cGAS Axis to Mitigate Disc Degeneration and Aberrant Innervation

Advanced Science, EarlyView.
RU@PEI‐ZIF integrates dsDNA scavenging with local cGAS inhibition to suppress the dsDNA–cGAS–STING/Netrin‐1 axis in intervertebral disc degeneration. By attenuating nucleus pulposus cell senescence, inflammatory and matrix‐catabolic responses, and pathological sensory innervation, this dual‐functional nanoplatform preserves disc integrity and reduces ...
Zhaojun He, Tianyu Chen, Zezheng Liu, Xinlin Huang, Ruitangbin Jiang, Yihao Liu, Baojing Xu, Yuxiang Li, Kangning Zhao, Huibo Yan, Lei Zhou, Can Liu, Qingchu Li   +12 more
wiley   +1 more source

Design and Optimization of Double-Tail Dynamic Latch CMOS Comparator With Modified Widlar Current Source

Journal of Electrical and Computer Engineering
The comparator plays a vital role in analog-to-digital converters. In the emerging communication era, these converters are useful to connect the analog field to the digital field.
Tejender Singh, Suman Lata Tripathi
doaj   +1 more source

Design and Implementation of Low-Power Dynamic Comparator

, 2021
Dynamic comparators are highly utilized in design of high-speed digital circuits. More precisely, Low power and high-speed dynamic comparators are the key elements in manufacturing of CPUs in many electronic devices. These CPUs consist of many comparison
et. al., Nagesh Mantravadi ,
core  

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Disabling COMPASS Promoter Licensing Shifts HDAC‐Inhibited Gastric Cancer Toward Sustained Transcriptional Suppression During Recovery

Advanced Science, EarlyView.
Combined inhibition of the WDR5 WIN pocket and HDAC activity converts SAHA‐induced hyperacetylation into a promoter state with reduced WDR5–COMPASS association and H3K4me3. MYC/E2F‐linked nascent transcription and biosynthetic recovery are suppressed, while apoptosis and senescence‐like features increase, resulting in sustained growth inhibition in ...
Jintian Song, Hui Yu, Jianping Jiang, Zhihui Jiang, Zhongshi Hong, Xu Zhang, Luchuan Chen, Shenghong Wei, Yi Wang   +8 more
wiley   +1 more source