Results 201 to 210 of about 7,385,916 (287)

Time to Enhancement Measured From Ultrafast Dynamic Contrast-Enhanced MRI for Improved Breast Lesion Diagnosis. [PDF]

J Breast Imaging
Chen YA, Kazerouni AS, Phelps MD, Hippe DS, Youn I, Lee JM, Partridge SC, Rahbar H.   +7 more
europepmc   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

Advanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu, Xi Li, Wenxuan He, Fenglin Li, Qican Ou, Yao Liu, Jiang Lei, Yanzi Bao, Huaxin Huang, Wei Feng, Yuanguang Tang, Xiaohui Qiu, Lu Gan, Yuefei Shen, Jin Wang, Yousheng Xiao   +15 more
wiley   +1 more source

Dual-encoder 3D transformer-based U-Net with temporal attention for non-mass enhancement segmentation in breast dynamic contrast-enhanced MRI. [PDF]

Radiol Phys Technol
Kosugi T, Nakayama R, Sakai K, Goto M.
europepmc   +1 more source

Targeted Perturbation of Mitochondrial Energy Metabolism via Thermoelectric Nanoflowers for Enhanced Cuproptosis Echoed With Immunotherapy

Advanced Science, EarlyView.
We fabricated a thermoelectric nanomedicine to disrupt the ATP energy supply for the copper transporter ATP7B, thereby enhancing cuproptosis and achieving synergistic immunotherapy for anti‐tumor purposes. The fabricated TBCT NFs can efficiently disrupt the electron transport chain function via superoxide‐induced NADH oxidation, leading to ATP ...
Haoyang Du, Chao Xu, Hao Wang, Bo Peng, Peng Liu, Wei Gao, Tao Ye, Xinyuan Yu, Ying Shi, Jiaxin Liu, Tiancong Zhao, Bin Sun, Piaoping Yang, Manjie Zhang   +13 more
wiley   +1 more source

The feasibility of the radiomics models for tumor-infiltrating lymphocytes level prediction in breast cancer based on dynamic contrast-enhanced MRI. [PDF]

BMC Med Imaging
Peng Y, Hu X, Liu Y, Chen D, Chen X, Wang Y, Wang S.   +6 more
europepmc   +1 more source

Mitochondria‐Targeting Iron–Carbon Nanozymes Combat Hepatic Ischemia–Reperfusion Injury via the Dual Mechanisms of Respiratory Chain Remodeling and Pyroptosis Inhibition With MRI Monitoring

Advanced Science, EarlyView.
A mitochondrial‐targeted FeCD‐SS31 nanoplatform integrates ROS‐responsive SS31 release with cascade antioxidant Fe3O4/CDs cores to suppress both de novo and existing ROS. By restoring mitochondrial complex integrity and blocking caspase‐1–GSDMD‐N pyroptosis, it reduces neutrophil infiltration and alleviates hepatic ischemia–reperfusion injury, while ...
Qianying Du, Lian Xu, Tingting Xia, Wenli Zhang, Sijin Chen, Xiyue Rong, Ying Luo, Yi Wang, Jia Liu, Yun Liu, Haitao Ran, Dajing Guo, Jie Xu   +12 more
wiley   +1 more source

Evaluation of Gemini 2.0 AI in Classifying Breast Lesion Status From Dynamic Contrast-Enhanced MRI: A Preliminary Study. [PDF]

Cureus
Chetla N, Naidu T, Patel S, Bouras A, Kacham H, Bonagiri V, Zaman N.   +6 more
europepmc   +1 more source

Physics‐Guided Multi‐Channel Restoration for Efficient and Accurate Atomic Force Microscopy Imaging

Advanced Science, EarlyView.
Schematic figure of restoring noisy atomic force micrscopy (AFM) image via physics‐guided multi‐channel restoration. The lighter neural network models with multiple‐channel input from auxiliary signals outperforms heavier model with single‐channel input.
Jaeuk Sung, Hongseok Kim, Seungjae Heo, Jin Tae Moon, Jangwoo Ko, Panithan Sriboriboon, Dong‐Gyu Lee, Sanghyun Jo, Hee Han, Jungho Ryu, Woo Lee, Jinseong Heo, Hyun‐Cheol Song, Yunseok Kim   +13 more
wiley   +1 more source

Diagnostic values of diffusion-weighted imaging and dynamic contrast-enhanced MRI in the pathological grading of adenoid cystic carcinoma. [PDF]

BMC Med Imaging
An P, Jiang N, Li J, Li W, Zhou K, Xin J, Jing P, Sun L.   +7 more
europepmc   +1 more source

Precision Nanomedicine for Traumatic Neural Injury: Functional Paradigms and Translational Frameworks

Advanced Science, EarlyView.
This review presents a pathology‐driven framework unifying nanomedicine across TBI, SCI, and PNI. Epidemiological evidence and comparative single‐cell transcriptomic reanalysis define shared pathological modules, injury‐specific effectors, and therapeutic bottlenecks. Six functional paradigms connect nanomaterial structure and biological fate to injury‐
Mouyuan Sun, Shuangyang Li, Zhixu He, Jingyi Xie, Yaxian Luo, Xuankai Fan, Jingyu Zhang, Luying Qin, Lianjie Peng, Tao Qiu, Tian Zhang, Huiming Wang, Mengfei Yu   +12 more
wiley   +1 more source