Results 21 to 30 of about 455,930 (238)
Physics and Imaging in Radiation OncologyBackground and purpose: Magnetic resonance imaging (MRI) plays a central role in evaluating treatment response after stereotactic body radiotherapy (SBRT) for spinal metastases.
Keivan Daneshvar +8 more
doaj +1 more source
Afromaison. Project objective, work progress and achievements project management : Core part of the mid-term report [PDF]
, 2012 Natural resources are essential for maintaining or improving people's livelihood, especially in Africa. Integrated management of natural resources (INRM) is a way to maintain ecosystems capacity to produce a broad range of goods and services considering ...
D'Haeyer, Tom +2 more
core
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Adaptive Design Evaluator: A Co‐Assessment Tool for Early Planning Stages
Urban PlanningMany municipalities face intense development pressures, challenging them to ensure spatial sustainability. Current assessment methods are designed for larger projects and are often time‐consuming and resource intensive.
Julia Forster +2 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Organic Writing Assessment: Dynamic Criteria Mapping in Action
, 2009 Educators strive to create "assessment cultures" in which they integrate evaluation into teaching and learning and match assessment methods with best instructional practice. But how do teachers and administrators discover and negotiate the values that underlie their evaluations? Bob Broad's 2003 volume, What We Really Value, introduced dynamic criteria
Broad, Bob +4 more
openaire +3 more sources
Hybrid MCDM–Isolation Forest approach for spatiotemporal landslide mapping
Open GeosciencesLandslide assessment requires static factors defining baseline conditions and dynamic factors acting as triggers. However, integrating various factors into susceptibility assessments increases uncertainty in multi-criteria decision making (MCDM ...
Jiang Bingqi +4 more
doaj +1 more source