Results 41 to 50 of about 455,930 (238)

Architecture of Environmental Risk Modelling: for a faster and more robust response to natural disasters [PDF]

open access: yes, 2014
Demands on the disaster response capacity of the European Union are likely to increase, as the impacts of disasters continue to grow both in size and frequency.
de Rigo, Daniele   +2 more
core  

Assessing digital preservation frameworks: the approach of the SHAMAN project [PDF]

open access: yes, 2009
How can we deliver infrastructure capable of supporting the preservation of digital objects, as well as the services that can be applied to those digital objects, in ways that future unknown systems will understand?
Elena, M.   +5 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Ecological flow-driven multifunctionality: A Nature-based Solutions framework for urban ecological corridor planning in high-density cities

open access: yesEcological Indicators
This study develops an ecological flow driven framework, grounded in Nature-based Solutions (NbS), that upgrades the canonical source, resistance, and path paradigm for urban ecological corridors to the realities of high-density cities.
Lang Zhang   +5 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Mapping the vulnerable: A framework for analyzing urban social vulnerability and its societal impact

open access: yesSocietal Impacts
Widespread high exposure and vulnerability, coupled with inadequate adaptive capacity, underscore the urgent need for targeted interventions and policies to enhance urban resilience.
Subham Roy   +3 more
doaj   +1 more source

Introducing Adaptive Incremental Dynamic Analysis: A New Tool for Linking Ground Motion Selection and Structural Response Assessment [PDF]

open access: yes, 2013
Adaptive Incremental Dynamic Analysis (AIDA) is a novel ground motion selection scheme that adaptively changes the ground motion suites at different ground motion intensity levels to match hazardconsistent properties for structural response assessment ...
Baker, Jack W., Lin, Ting
core   +1 more source

A Wii Bit of Fun: A Novel Platform to Deliver Effective Balance Training to Older Adults [PDF]

open access: yes, 2015
BACKGROUND: Falls and fall-related injuries are symptomatic of an aging population. This study aimed to design, develop, and deliver a novel method of balance training, using an interactive game-based system to promote engagement, with the inclusion of ...
Craig, Cathy   +4 more
core   +3 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

open access: yesMolecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski   +9 more
wiley   +1 more source

GIS-Based Framework for Integrating Urban Heritage and Lighting Planning

open access: yesBuildings
This study develops a GIS-based, heritage-sensitive urban lighting framework for Niğde, Türkiye, integrating Sentinel-2 MSI Level-2A imagery (10 m), ASTER DEM, and municipal cadastral data.
Orhun Soydan, Mertkan Fahrettin Tekinalp
doaj   +1 more source

Home - About - Disclaimer - Privacy