Results 1 to 10 of about 785,141 (269)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
A TCN-BiLSTM and ANR-IEKF Hybrid Framework for Sustained Vehicle Positioning During GNSS Outages
SensorsThe performance of integrated Global Navigation Satellite System and Inertial Navigation System (GNSS/INS) navigation often declines in complex urban environments due to frequent GNSS signal blockages.
Senhao Niu +5 more
doaj +1 more source
Natural plant growth and development achieved in the IPK PhenoSphere by dynamic environment simulation. [PDF]
Nat Commun, 2023 Heuermann MC +3 more
europepmc +1 more source
Path planning in dynamic environments.
, 2007 Path planning plays an important role in various fields of application, such as CAD design, computer games and virtual environments, molecular biology, and robotics. In its most general form, the path planning problem is formulated as finding a collision-free path for a moving entity between a start and a goal configuration in an environment containing
openaire +2 more sources
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A DH-KSVD Algorithm for Efficient Compression of Shock Wave Data
Applied SciencesTo address low training efficiency and poor reconstruction in traditional K Singular Value Decomposition (KSVD) for compressive sensing of shock wave signals, this study proposes an improved algorithm, DH-KSVD, integrating dynamic pruning and hybrid ...
Jiarong Liu, Yonghong Ding, Wenbin You
doaj +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Applied SciencesUnderwater image analysis is affected by light scattering, wavelength-dependent attenuation, low contrast, and suspended particles, which reduce the discriminative visual features.
Abdullah Faiz, Kun Li, Ping Chen
doaj +1 more source
Incremental Learning of Goal-Directed Actions in a Dynamic Environment by a Robot Using Active Inference. [PDF]
Entropy (Basel), 2023 Matsumoto T, Ohata W, Tani J.
europepmc +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source