Results 41 to 50 of about 4,336,710 (302)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Cauchy problem for generalized abstract Boussinesq equations

open access: yes, 2016
In this paper, the existence and uniqueness of solution of the Cauchy problem for abstract Boussinesq equations is obtained. By applying this result, the Wentzell-Robin type mixed problem for Boussinesq equations and the Cauchy problem for finite or ...
Shakhmurov,V.B.
core   +2 more sources

Hybrid Force and Motion Control of a Three-Dimensional Flexible Robot Considering Measurement Noises

open access: yesMachines, 2022
This work addresses the end-effector trajectory-tracking force and motion control of a three-dimensional three-link robot considering measurement noises. The last two links of the manipulator are considered as structurally flexible.
Sinan Kilicaslan   +2 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Measure functional differential equations and functional dynamic equations on time scales

open access: yes, 2012
We study measure functional differential equations and clarify their relation to generalized ordinary differential equations. We show that functional dynamic equations on time scales represent a special case of measure functional differential equations ...
Mesquita, Jaqueline Godoy   +5 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Earthquake dynamic response of large flexible multibody systems [PDF]

open access: yesMechanical Sciences, 2013
In the paper dynamics of large flexible structures imposed on earthquakes and high amplitude vibrations is regarded. Precise dynamic equations of flexible systems are the basis for reliable motion simulation and analysis of loading of the design scheme ...
E. V. Zahariev
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Intervals of Existence of Dynamic Equations on Particular Time Scales [PDF]

open access: yes, 2012
Color poster with text, graphs, and diagrams.This study analyzed dynamic equations on time scales and the intervals of existence of solutions on a special class of time scales consisting of a finite number of intervals.University of Wisconsin--Eau Claire
Paquin, Robert J.
core  

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