Results 31 to 40 of about 216,212 (263)
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Dynamic equilibrium and oscillations of stars with uneven mass of particles of the medium
Известия высших учебных заведений. Поволжский регион: Физико-математические науки, 2023 Background. The study examines a model of the structure and evolution of stars in dynamic equilibrium, supplemented by a new analysis of the zonal flow velocity, new elements for describing the evolution of the heat flow, and the introduction of unequal ...
Viktor M. Zhuravlev
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Путеводитель предпринимателя, 2020 The article analyzes the conceptual bases, organizational forms and sources of financing of innovative development of regions and municipalities. An innovative model is considered as a system that provides the sustainable development of the national ...
E. F. Nikitskaya, M. A. Valishvili
doaj
Study on the ageing of insulators based on the surface charge accumulation process
The Journal of Engineering, 2019 In order to study the transient motion of the space charge around the air tower insulator and the charge distribution of the insulator, a two-dimensional mixed numerical model of the insulator string based on chemical reaction is proposed. The simulation
Gao Yaochong +6 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Colin Rowe and ' Dynamic Equilibrium'
Cuadernos de Proyectos Arquitectónicos, 2015 In 1944 Gyorgy Kepes published what undoubtless will be his most influential text, "The language of vision". What Kepes tried to do was a guide of grammar and syntax of vision, which allows to face art as purely sensory experience or just visual ...
Pablo López Marín
doaj
International Journal of Public HealthObjectivesOur objective was to assess morbidity trends in Europe and to classify European countries based on population ageing theories: the compression, expansion and dynamic equilibrium of morbidity.MethodsThe proportions of healthy life years were ...
Jakub Straka +3 more
doaj +1 more source