Results 51 to 60 of about 756 (245)

A Novel Approach Based on Stochastic Hybrid Fault Tree to Compare Alternative Flare Gas Recovery Systems

open access: yesIEEE Access, 2021
Flaring has always been an inseparable part of oil production and exploration. Previously, waste gas collected from different parts of facilities was released for safety or operational reasons and combusted on top of a flare stack since there was not the
Soheyl Moheb Khodayee   +2 more
doaj   +1 more source

From model, signal to knowledge: a data-driven perspective of fault detection and diagnosis [PDF]

open access: yes, 2013
This review paper is to give a full picture of fault detection and diagnosis (FDD) in complex systems from the perspective of data processing. As a matter of fact, an FDD system is a data-processing system on the basis of information redundancy, in which
Dai, Xuewu, Gao, Zhiwei
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

An evidence-based risk decision support approach for metro tunnel construction

open access: yesJournal of Civil Engineering and Management, 2022
The risk-informed decision-making of metro tunnel project is often faced with the problem of inadequate utilization of available information. In order to address the epistemic uncertainty problem caused by insufficient utilization of information in ...
Yifan Guo   +3 more
doaj   +1 more source

Synthesizing FDIR Recovery Strategies From Non-Deterministic Dynamic Fault Trees [PDF]

open access: yes, 2017
Redundancy concepts are an integral part of the design of space systems. Deciding when to activate which redundancy and which component should be replaced can be a difficult task.
Gerndt, Andreas   +5 more
core   +1 more source

Attack Trees vs. Fault Trees: Two Sides of the Same Coin from Different Currencies [PDF]

open access: yes, 2021
This work compares formal approaches to define and operate with attack trees and fault trees. We start by investigating similarities between the syntactic structure, semantics, and qualitative analysis, of static attack trees and fault trees.
Budde, Carlos E.   +5 more
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Dynamic Assessment of the Probability of Release Caused by Equipment Deterioration

open access: yesChemical Engineering Transactions, 2022
Deterioration due to the corrosion is the cause of undesired consequences in establishments at major accident hazard as it increases the potential for release of hazardous substances.
Maria Francesca Milazzo   +4 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

open access: yesFEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong   +3 more
wiley   +1 more source

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