Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
[Relationship between dynamic CT angiography-based collateral flow evaluation and outcome of patients with stroke induced by acute basilar artery occlusion]. [PDF]
, 2017 Zhen‐Zhen Lai +5 more
openalex +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Frontiers in Earth ScienceShallow landslides and debris flows triggered by heavy rainfall are widespread catastrophic geological disasters in mountainous areas. Landslides with complex terrain are often the material source of debris flows as a disaster chain. However, the failure
Fen Wang +7 more
doaj +1 more source
A study of fluid dynamics of gaseous nuclear rockets Quarterly progress report, period ending Jun. 30, 1968 [PDF]
Bibliography on vortex flows for fluid dynamic containment of gaseous nuclear rocket ...
Lewellen, W. S.
core +1 more source
I. Age-depentent spatially distributed two sex model of population dynamics with pair formation and dynamic analysis via computer simulations : II. An ecological model for red tide plankton and numerical simulation : III. Flow analysis around structures in environmental fluids and its application to environmental restoration technology [PDF]
, 2004 Shinnosuke Ôharu +11 more
openalex +1 more source
Dynamic energy flow analysis of electricity-heating based integrated energy system
, 2023 Qiong Wu +5 more
openalex +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source