Results 21 to 30 of about 254,030 (216)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Runners on footbridges – a new VGRF model for heel strike running technique [PDF]

MATEC Web of Conferences, 2019
In the paper the models of dynamic forces generated by people running referred to two running techniques i.e. forefoot strike running and heel strike (rearfoot strike) running are presented.
Pańtak Marek
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Theoretical assessment of the distribution of dynamic interaction forces of the "rolling stock-track" system along the length of subway railway switches

Збірник наукових праць Державного університету інфраструктури та технологій: серія "Транспортні системи і технології"
One of the peculiarities for switch operation is the increased level of force interaction between the bearing elements of the switch and the rolling stock chassis, which causes increased requirements for strength, stability, reliability and durability ...
Олена Олійник, Володимир Бойко, Віталій Молчанов, Ольга Сорока   +3 more
doaj   +1 more source

Loading of the hip and knee joints during whole body vibration training.

PLoS ONE, 2018
During whole body vibrations, the total contact force in knee and hip joints consists of a static component plus the vibration-induced dynamic component.
Georg Bergmann, Ines Kutzner, Alwina Bender, Jörn Dymke, Adam Trepczynski, Georg N Duda, Dieter Felsenberg, Philipp Damm   +7 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Statistical comparison of fleet types on track forces in Isfahan metro using field test data [PDF]

International Journal of Railway Research
The maintenance of a railway track in the urban rail fleet includes an intensive schedule of maintenance operations, which must be carried out by personnel during night time shift to ensure the safety of the system.
Habibollah Molatefi, Morad Shadfar, Amir Hosein Bakhshian   +2 more
doaj  

Associations between Body Segment Mass and Punch, Front Kick, or Countermovement Jump Performance in Military Cadets

Sports
Despite the recognized influence of body mass on combat techniques, the relationship between body segment mass (BSM) and combat moves remains unexplored.
Michal Vagner, Jan Malecek, Vladan Olah, Petr Stastny   +3 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source