Results 71 to 80 of about 113,132 (262)
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Advances in Civil EngineeringUnderstanding the effects of harmonic excitation on rock failure is essential in terms of enhancing rock-breaking efficiency. Although a series of dynamic cracking have been studied, investigations on the dynamic behavior of rock in different stages of ...
Zhao Zhang, Zewen Gu, Jianlin Liu
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
A dynamic fragmentation of the misery index in Nigeria
Cogent Economics & Finance, 2017 This study adopts a dynamic approach to compute the level of economic distress in Nigeria. Quarterly series from 2002Q1 to 2016Q4 were utilized in computing the index.
K. Moses Tule +3 more
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Decision procedure for a fragment of dynamic logic
Lietuvos matematikos rinkinys, 2001 There is not abstract.
openaire +3 more sources
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
Two-dimensional dynamic simulation of fracture and fragmentation of solids
Computer Assisted Methods in Engineering and Science, 2023 We present a two-dimensional discrete model of solids that allows us to follow the behavior of the solid body and of the fragments well beyond the formation of simple cracks.
Ferenc Kun +3 more
doaj
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Experimental Technique for Dynamic Fragmentation of Liquid-Driving Expanding Ring
EPJ Web of Conferences, 2018 Expanding ring experiment is an important method for dynamic fragmentation of solid under 1D tensile loading. Based on the split Hokinson pressure bar (SHPB), a liquid-driving experimental technology was developed for conducting expanding ring tests. The
Zhang Jia +3 more
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