Results 61 to 70 of about 113,132 (262)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Dynamic compression behaviour and fragmentation characteristics of sandstone with different water contents

Geomechanics and Geophysics for Geo-Energy and Geo-Resources
Dynamic compression properties and fragmentation characteristics of water-bearing rocks were crucial for the effective excavation of tunnels and mining engineering in groundwater environments.
Tong Guo, Yang Sang, Jianchun Li, Dapeng Wang   +3 more
doaj   +1 more source

3D Fragmentation Metric and RCSA Scheme for Space Division Multiplexing Elastic Optical Networks

IEEE Access, 2020
The space division multiplexing elastic optical networks (SDM-EONs) based on multi-core fiber (MCF) are an effective solution to improve transmission capacity.
Juan Zhang, Bowen Bao, Qiuyan Yao, Danping Ren, Jinhua Hu, Jijun Zhao   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Energy Dissipation and Dynamic Fragmentation of Alkali-Activated Rubber Mortar under Multi-Factor Coupling Effect. [PDF]

Materials (Basel), 2022
Shi Y, Ma Q, Xu Z, Ma D, Yang X, Gu Y.
europepmc   +1 more source

Identify detailed dynamic processes and driving forces of forest fragmentation based on explainable AI: Taking a global biodiversity priority area as a case

Global Ecology and Conservation
Global forests are increasingly fragmented by population growth and intensified human activities, threatening the stability and sustainability of forest ecosystems.
Shuang Liu, Ziheng Huang, Qingjie Fu, Jin Chen, Xiaohui Chen, Min Wu, Zhilong Wu, Limin Ye, Xisheng Hu   +8 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Statistical prediction method of inclined shaft blasting fragmentation based on dynamic damage distribution in excavated rock mass

Scientific Reports
To address pilot shaft blockage and fragmentation control issues in inclined shaft blasting excavation, this study investigated the coupling mechanism between excavated rock mass damage distribution and fragmentation gradation using the Tianchi Pumped ...
Xin Wei, Zhan Shen, Kaiwen Song, Dengxing Qu, Xinping Li, Yi Luo, Tingting Liu   +6 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source