Results 71 to 80 of about 5,056,995 (308)

How Digital Strategy and Management Games Can Facilitate the Practice of Dynamic Decision-Making

open access: yesEducation Sciences, 2020
This paper examines how digital strategy and management games that have been initially designed for entertainment can facilitate the practice of dynamic decision-making.
André Czauderna, Alexandra Budke
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Du bruit au langage : écologie des sons signifiants dans Oddworld: Abe’s Oddysee et Oddworld: Abe’s Exoddus

open access: yesSciences du Jeu, 2022
Our paper analyses the integration of human language in Oddworld: Abe’s Oddysee (Oddworld Inhabitants) and Oddworld: Abe’s Exoddus (Oddworld Inhabitants), two video games respectively released in 1997 and 1998 on PlayStation.
Mathieu Goux
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

open access: yesMolecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad   +2 more
wiley   +1 more source

Basketball Elements in Physical Education Lessons for Primary School Students

open access: yesACROSS, 2022
There are several ways to optimize the training process using various complexes of exercises, dynamic games and much more in physical education in school, including the primary level.
Constantin CIORBĂ
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

DEVELOPING MOTOR QUALITIES SPEED AND SKILL USING MOTION GAMES AT FOURTH GRADE LEVEL [PDF]

open access: yesAnnals of the “Ştefan cel Mare” University: Physical Education and Sport Section - The Science and Art of Movement, 2021
Through this study I want to confirm the need to use dynamic games in physical education classes and to demonstrate the efficiency that movement games have in the development of motor skills.
Benedek Florian
doaj  

Tingkat Kesulitan Dinamis Menggunakan Logika Fuzzy pada Game Musik Tradisional Jawa Tengah

open access: yesJurnal ELTIKOM: Jurnal Teknik Elektro, Teknologi Informasi dan Komputer, 2021
The culture in Indonesia is very diverse, one of which is traditional songs. However, knowledge of traditional songs is still small. Digital Games can spread knowledge about traditional songs, one of which is Central Javanese traditional songs.
Kadhana Reya Wisinggya   +4 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

Rethinking climate agreements: self-enforcing strategies for emission reduction through sanctions

open access: yesEnvironmental Research Letters
Although climate change is expected to cause significant negative impacts, climate treaties give hope for reducing greenhouse gas (GHG) emissions, potentially leading to less severe climate change. However, climate change is a public bad: If each country
Adam Lampert
doaj   +1 more source

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