Results 71 to 80 of about 232,761 (262)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Dual-Channel Dynamic Gated Spatio-Temporal Graph for Traffic Flow Forecasting
IEEE AccessTraffic flow forecasting is a critical and essential technology in the field of Intelligent Transportation Systems (ITS), as it plays a pivotal role in optimizing traffic management, improving road safety, and enhancing the overall efficiency of ...
Chao Wang +5 more
doaj +1 more source
Attention-based message passing and dynamic graph convolution for spatiotemporal data imputation
Scientific Reports, 2023 Although numerous spatiotemporal approaches have been presented to address the problem of missing spatiotemporal data, there are still limitations in concurrently capturing the underlying spatiotemporal dependence of spatiotemporal graph data ...
Yifan Wang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Transfer-Aware Graph U-Net with Cross-Level Interactions for PolSAR Image Semantic Segmentation
Remote SensingAlthough graph convolutional networks have found application in polarimetric synthetic aperture radar (PolSAR) image classification tasks, the available approaches cannot operate on multiple graphs, which hinders their potential to generalize effective ...
Shijie Ren, Feng Zhou, Lorenzo Bruzzone
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Route planning in dynamic graphs with linear changing and preprocessing for speed-up [PDF]
Transport Problems, 2010 The goal of this paper is to work out a concept for route planning in a road network, where the costs of roads are not constant, but changing in a linear way.
Gábor SZŰCS
doaj
IEEE Access, 2019 Social network data publishing is dynamic, and attackers can perform association attacks based on social network directed graph data at different times.
Xiaolin Zhang +3 more
doaj +1 more source