Results 81 to 90 of about 232,761 (262)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
GIScience & Remote SensingTraffic congestion propagation poses significant challenges to urban sustainability, disrupting spatial accessibility. The cascading effects of traffic congestion propagation can cause large-scale network disruptions.
Weihua Huan +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
The Analysis of Complex Networks with Dynamic Graph Visualization
Моделирование и анализ информационных систем, 2010 The work describes a technique for dynamic graph visualization that helps us to analyze complex networks. Our method builds layouts for a sequence of graphs, while preserving the mental map. We show how to modify force-directed algorithms for the dynamic
S. N. Pupyrev, A. V. Tikhonov
doaj
Spatial-Pooling-Based Graph Attention U-Net for Hyperspectral Image Classification
Remote SensingIn recent years, graph convolutional networks (GCNs) have attracted increasing attention in hyperspectral image (HSI) classification owing to their exceptional representation capabilities.
Qi Diao +5 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Robust Unsupervised Multi-View Feature Learning With Dynamic Graph
IEEE Access, 2019 Graph-based multi-view feature learning methods learn a low-dimensional embedding of the data by modeling the affinity correlations with a graph to reduce the dimension.
Yikun Li +4 more
doaj +1 more source