Results 21 to 30 of about 18,083 (236)

Research on Dynamic Redundancy Reliability Mechanisms Based on Multi-core HeterogeneousOperating Systems [PDF]

Jisuanji kexue
In response to the hybrid deployment requirements and functional safety needs of current embedded systems,this paper proposes a dynamic heterogeneous redundant operating system architecture,DHR-OS.Designed for hybrid deployment,the architecture features ...
HE Ruiqi, ZHANG Kailong, WU Jinfei, YU Qiang, ZHANG Jiaming
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Implementation architecture of mimic security defense based on SDN

网络与信息安全学报, 2017
To deal with the attacks employing unknown security vulnerabilities or backdoors which are difficult for traditional defense techniques to eliminate,mimic security defense (MSD) that employs “dynamic,heterogeneity,redundancy (DHR)” mechanism can increase
Zhen-peng WANG,Hong-chao HU,Guo-zhen CHENG, Chuan-hao ZHANG   +1 more
doaj   +3 more sources

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Cyber Resilience Enabled by Endogenous Safety and Security: Vision, Techniques, and Strategies

中国工程科学, 2023
Cyber resiliency engineering is a technical approach embraced by countries and regions such as the United States and Europe to implement digital transformation and address network security challenges under new circumstances.
Wu Jiangxing , Zou Hong , Xue Xiangyang , Zhang Fan , Shang Yuting   +4 more
doaj   +1 more source

Research on anti-attack performance of a private cloud safety computer based on the Markov-Percopy dynamic heterogeneous redundancy structure

Transportation Safety and Environment, 2022
Abstract With the increasing computing demand of train operation control systems, the application of cloud computing technology on safety computer platforms of train control system has become a research hotspot in recent years. How to improve the safety and availability of private cloud safety computers is the key problem when applying ...
Jiakun Wen, Zhen Liu, Huan Ding
openaire   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Cyberspace Endogenous Safety and Security

Engineering, 2022
Uncertain security threats caused by vulnerabilities and backdoors are the most serious and difficult problem in cyberspace. This paper analyzes the philosophical and technical causes of the existence of so-called “dark functions” such as system ...
Jiangxing Wu
doaj   +1 more source