Results 71 to 80 of about 5,655,620 (210)

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Improving left ventricular outflow tract obstruction repair in common atrioventricular canal defects

, 2012
Left ventricular outflow tract obstruction (LVOTO) is the second most frequent reason for reoperation after atrioventricular canal (AVC) defect repair.
Emani, Sitaram, Pigula, Frank A, Myers, Patrick Olivier, del Nido, Pedro J, Baird, Christopher W, Marx, Gerald R, Mayer, John E (Jr)   +6 more
core   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

British Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral, Nicholas Monaco, Daniel I. Brierley, Monica Imbernon   +3 more
wiley   +1 more source

3D transparent technology displays the developmental patterns of ductus arteriosus morphology in chicken embryos before and after birth

Journal of Anatomy, EarlyView.
At the eighth week of human embryonic development, 3D transparent imaging enables clear visualization of the outflow tract's morphological features, revealing its anatomical components in detail. Abstract The ductus arteriosus (DA) is a critical fetal vascular structure that shunts blood from the pulmonary artery to the aorta, bypassing the non ...
Conghong Xu, Lidi Li, Xiu Wu, Yanli Zhang, Chuanye Wu, Juan Chen, Haihua Gao, Zhenglai Ma   +7 more
wiley   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Exploring Morphologic and Functional Variants in Hypertrophic Cardiomyopathy: An Echocardiographic and Doppler Review

Diagnostics
Hypertrophic cardiomyopathy (HCM) is a complex and heterogeneous myocardial disorder, best evaluated with echocardiography for initial diagnosis, risk stratification, and longitudinal monitoring.
Kamil Stankowski, Fabrizio Celeste, Manuela Muratori, Francesco Cannata, Nicola Cosentino, Fabio Fazzari, Laura Fusini, Daniele Junod, Massimo Mapelli, Riccardo Maragna, Andrea Baggiano, Saima Mushtaq, Luigi Tassetti, Gianluca Pontone, Mauro Pepi   +14 more
doaj   +1 more source

Percutaneous pulmonary valve implantation in humans - Results in 59 consecutive patients [PDF]

, 2005
Background - Right ventricular outflow tract (RVOT) reconstruction with valved conduits in infancy and childhood leads to reintervention for pulmonary regurgitation and stenosis in later life.Methods and Results - Patients with pulmonary regurgitation ...
Coats, L, Razavi, RS, Bonhoeffer, P, Boudjemline, Y, Khambadkone, S, Pellerin, D, Deanfield, J, Tsang, V, Derrick, G, Cooper, J, Taylor, A, Muthurangu, V, Hegde, SR   +12 more
core  

Energetic microdomains and the vascular control of neuronal and muscle excitability: Toward a unified model

The Journal of Physiology, EarlyView.
Abstract figure legend The capillary–mitochondria–ion channel (CMIC) axis scales structural resources to match functional workload. (Left) In settings of restricted energetic capacity (e.g. cortical neurons), sparse capillary networks and modest mitochondrial pools set a lower energetic ceiling, sufficient to support phasic, low‐workload excitability. (
L. Fernando Santana, Scott Earley
wiley   +1 more source

A Benign Cardiac Growth but Not So Indolent

Case Reports in Cardiology, 2016
Cardiac lipomatous hypertrophy is a rare benign condition that usually involves the interatrial septum. Due to its benign nature it rarely requires intervention. Its presence outside the interatrial septum is reported infrequently.
Adil S. Wani, Sahadev T. Reddy, Lakshmi Harinath, Robert W. W. Biederman   +3 more
doaj   +1 more source

Successful Percutaneous Septal Alcohol Ablation After Surgical Myectomy

Biomolecules & Biomedicine, 2010
Hypertrophic obstructive cardiomyopathy (HOCM) is a primary, usually familial and genetically fixed myocardial hypertrophy, with dynamic left ventricular outflow tract obstruction.
Mehmed Kulić, Muhamed Spužić, Elnur Tahirović, Šejla Šehović, Vedad Mujačić, Darko Zorman, Vladimir Velebit   +6 more
doaj   +1 more source