Results 101 to 110 of about 1,355,767 (260)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Load-shortening behavior of an initially curved eccentrically loaded column [PDF]

To explore the feasibility of using buckled columns to provide a soft support system for simulating a free-free boundary condition in dynamic testing, the nonlinear load-shortening behavior of initially imperfect, eccentrically loaded slender columns is ...
Fichter, W. B., Pinson, Mark W.
core   +1 more source

Effect of bedding dip angle and dynamic load on spatial variation of microscopic failure stress of shale. [PDF]

Sci Rep, 2023
Wang M, Shao X, Pan X.
europepmc   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Different Conical Angle Connection of Implant and Abutment Behavior: A Static and Dynamic Load Test and Finite Element Analysis Study. [PDF]

Materials (Basel), 2023
Körtvélyessy G, Szabó ÁL, Pelsőczi-Kovács I, Tarjányi T, Tóth Z, Kárpáti K, Matusovits D, Hangyási BD, Baráth Z.   +8 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Study of Apollo water impact. Volume 8 - Unsymmetric shells of revolution analysis Final report [PDF]

Numerical analysis of static, and dynamic shell response to water impact ...
Cappelli, A. P., Nishimoto, T., Pauley, K. E., Radkowski, P. P.   +3 more
core   +1 more source

A Virtual Machine Consolidation Algorithm Based on Dynamic Load Mean and Multi-Objective Optimization in Cloud Computing. [PDF]

Sensors (Basel), 2022
Li P, Cao J.
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

A Study on the Design Depth of Permeable Road Pavement through Dynamic Load Experiment. [PDF]

Materials (Basel), 2022
Hsing CH, Siao JH, Wang YM.
europepmc   +1 more source