Results 51 to 60 of about 280,732 (268)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

On the Prediction of the Strip Shape in a Cold Rolling Mill (1700 mm)

The Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2008
In this paper is shown a new way for predicting the precision of laminated strip in a cold rolling mill (1700 mm). The increasing demands on the quality of rolled strip; need new technology for monitoring the strip shape, by using complex system control ...
Stefan DRAGOMIR, Georgeta DRAGOMIR, Marian BORDEI   +2 more
doaj  

Mechanical response and energy dissipation law of rock-like mass with internal fractures under dynamic load

Meitan kexue jishu
The strength of coal, mudstone, sandstone and other common rocks in the surrounding rock of deep roadway is low and the fractures are developed. Dynamic disasters are prone to occur in the complex mechanical environment of deep roadway.
Lishuai JIANG, Yiming YANG, Yang ZHAO, Haozhe LI, Qi WU, Xiaohan PENG   +5 more
doaj   +1 more source

Loading Dynamics of a Sliding DNA Clamp [PDF]

Angewandte Chemie, 2014
AbstractSliding DNA clamps are loaded at a ss/dsDNA junction by a clamp loader that depends on ATP binding for clamp opening. Sequential ATP hydrolysis results in closure of the clamp so that it completely encircles and diffuses on dsDNA. We followed events during loading of an E. coli β clamp in real time by using single‐molecule FRET (smFRET).
Cho, Won-Ki, Jergic, Slobodan, Kim, Daehyung, Dixon, Nicholas, Lee, Jong-Bong   +4 more
openaire   +5 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Resonance Conditions of Gearings. Part II: Experimental Research

Механика машин, механизмов и материалов, 2010
Results of experimental research of gearing resonance modes are considered. Serial specimens used in machine building were tested at universal stand of the open force contour.
N.N. Ishin , A.M. Goman , A.S. Skorokhodov   +2 more
doaj  

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Analysis of dynamic stress intensity factor of finite piezoelectric composite plate under a dynamic load [PDF]

FME Transactions, 2016
Piezoelectric materials are widely utilized in electronic device applications such as sensors. This paper investigates the dynamic response of a central crack in a finite piezoelectric layered composite plate under impact load. This novel project studies
Fotouhi Sakineh, Khalili Mohammad Reza S.   +1 more
doaj