Results 61 to 70 of about 4,475,198 (252)

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Response of the Bucket Foundation in Calcareous Sand under Horizontal Dynamic Load

open access: yes, 2010
Abstract: Experiments to determine the horizontal static bearing capacity are carried out first. The static bearing capacity is a reference for choosing the amplitudes of dynamic load. Then a series of experiments under dynamic horizontal load are
鲁晓兵, 王丽, 时忠民
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

On the Prediction of the Strip Shape in a Cold Rolling Mill (1700 mm)

open access: yesThe Annals of “Dunarea de Jos” University of Galati. Fascicle IX, Metallurgy and Materials Science, 2008
In this paper is shown a new way for predicting the precision of laminated strip in a cold rolling mill (1700 mm). The increasing demands on the quality of rolled strip; need new technology for monitoring the strip shape, by using complex system control ...
Stefan DRAGOMIR   +2 more
doaj  

Mechanical response and energy dissipation law of rock-like mass with internal fractures under dynamic load

open access: yesMeitan kexue jishu
The strength of coal, mudstone, sandstone and other common rocks in the surrounding rock of deep roadway is low and the fractures are developed. Dynamic disasters are prone to occur in the complex mechanical environment of deep roadway.
Lishuai JIANG   +5 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

Resonance Conditions of Gearings. Part II: Experimental Research

open access: yesМеханика машин, механизмов и материалов, 2010
Results of experimental research of gearing resonance modes are considered. Serial specimens used in machine building were tested at universal stand of the open force contour.
N.N. Ishin   +2 more
doaj  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

open access: yesFEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante   +10 more
wiley   +1 more source

Dynamic diffusion load balancing [PDF]

open access: yes
We present the first analysis of a simple discrete diffusion scheme for dynamic load balancing. In each round (1-epsilon)n tasks are (arbitrarily) generated over a set of n processors, load is balanced amongst neighbours in some underlying graph, then a ...
Berenbrink, Petra   +2 more
core  

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