Results 171 to 180 of about 543,871 (306)

Exact and heuristic reactive planning procedures for multi-mode resource-constrained projects. [PDF]

open access: yes
The multi-mode resource-constrained project scheduling problem (MRCPSP) involves the determination of a baseline schedule of the project activities, which can be executed in multiple modes, satisfying the precedence relations and resource constraints ...
Deblaere, Filip   +2 more
core  

Dynamic Event-Triggered Sliding-Mode Bipartite Consensus for Multi-Agent Systems With Unknown Dynamics [PDF]

open access: yes
This paper addresses a data-driven sliding mode bipartite consensus issue for nonlinear discrete-time multi-agent systems with antagonistic interactions and limited communication resources.
Zhao, Huarong   +3 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

Choice of Foreign Market Entry Mode - Cognitions from Empirical and Theoretical Studies [PDF]

open access: yes, 2004
Zhao X, Decker R. Choice of Foreign Market Entry Mode - Cognitions from Empirical and Theoretical Studies. Diskussionspapier - Fakultät für Wirtschaftswissenschaften, Universität Bielefeld. Vol 512.
Decker, Reinhold ; https://orcid.org/   +1 more
core   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Modelling departure time and mode choice [PDF]

open access: yes
As a result of increasing road congestion and road pricing, modelling the temporal response of travellers to transport policy interventions has rapidly emerged as a major issue in many practical transport planning studies.
Stephane Hess   +4 more
core  

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