Results 181 to 190 of about 28,178,522 (404)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Decision letter for "Dynamic‐transient modeling and performance evaluation of a multilayer variable‐capacitance energy conversion system"

, 2021

openalex   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Modified Smoothed Particle Hydrodynamics Approach for Modelling Dynamic Contact Angle Hysteresis [PDF]

, 2018
Yanyao Bao, Ling Li, Luming Shen, Chengwang Lei, Yixiang Gan   +4 more
openalex   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

eCherry: A Modelica Library for Modular Dynamic Modelling of Electrochemical Reactors

Electrochemical Science Advances
Electrochemical reactors offer promising pathways for defossilizing the chemical industry. To understand the operation as well as to evaluate and optimise their performance and efficiency, modelling presents a crucial tool.
Jan F. Pyschik, Katharina M. Ebeling, Georgia Ioanna Prokopou, Michael J. Rix, J. Raphael Seidenberg, Marius B. Kleiner, Matthias Leitl, Alexander Mitsos, Dominik Bongartz   +8 more
doaj   +1 more source

Labelled dataset for Ultra-Low Temperature Freezer to aid dynamic modelling & fault detection and diagnostics. [PDF]

Sci Data, 2023
Huang T, Nøstvik S, Bacher P, Jensen JK, Markussen WB, Møller JK.   +5 more
europepmc   +1 more source

Modeling of Double Star Induction Motors with Dynamic Eccentricity

, 2017
Zohra Yasmine Kecita, Mohamed Yazid Kaikaa, Redjem Rebbah, D Hadiouche, H Razik, A Rezzoug, L Alberti, N Bianchi, S Kia, H Henao, G-A Capolino, B Akin, U Orguner, H Toliyat, M Rayner, R Andriamalala, H Razik, L Baghli, F.-M Sargos, L Alberti, N Bianchi, L Tutelea, S Deaconu, N Budisan, I Boldea, D Dorrell, W Thomson, S Roach, N Al-Nuaim, H Toliyat, A Khezzar, M Hadjami, N Bessous, M Oumaamar, H Razik   +34 more
openalex   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source