Results 111 to 120 of about 8,084,139 (305)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A model for dynamic communicators [PDF]

, 2012
We develop and test an intuitively simple dynamic network model to describe the type of time-varying connectivity structure present in many technological settings.
Higham, Desmond J., Mantzaris, Alexander Vassilios   +1 more
core   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

A Spatio-Temporal Tensor Graph Neural Network-Based Method for Node-Link Prediction in Port Networks

IEEE Access
Port network information security has received extensive attention in recent years, in which the prediction of node links in the network is significant. A Port network is a dynamic network, and its structure changes continuously with time.
Zhixin Xia, Zhangqi Zheng, Feiyang Wei, Yongshan Liu, Lu Yu   +4 more
doaj   +1 more source

Recyclable Polydimethylsiloxane Network Crosslinked by Dynamic Transesterification Reaction

, 2017
This article reports preparation of a crosslinked polydimethylsiloxane (PDMS) network via dynamic transesterification reaction between PDMS-diglycidyl ether and pripol 1017 with Zn(OAc) 2 as the catalyst.
Zhao, Ning, Xu, Jian, Wenxing Liu, Zhang, Jiawei, Huan Zhang, Jiawei Zhang, Zhang, Huan, Li, Dongdong, Jian Xu, Cai, Chao, Chao Cai, Dongdong Li, Ning Zhao, Liu, Wenxing   +13 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Mining Dynamic Communities based on a Novel Link-Clustering Algorithm

International Journal of Information and Communication Technology Research, 2017
Discovering communities in time-varying social networks is one of the highly challenging area of research and researchers are welcome to propose new models for this domain.
Hamideh Sadat Cheraghchi, Ali Zakerolhosseini   +1 more
doaj  

Uncovering abnormal gray and white matter connectivity patterns in Alzheimer’s disease spectrum: a dynamic graph theory analysis for early detection

Frontiers in Aging Neuroscience
BackgroundAlzheimer’s disease (AD) requires early intervention at preclinical stages like subjective memory complaints (SMC). Traditional static brain network analyses lack sensitivity to detect early functional disruptions in SMC.
Juanjuan Jiang, Tao Kang, Ronghua Ling, Yingqian Liu, Jiuai Sun, Yiming Li, Xiaoou Li, Hui Yang, Bingcang Huang, the Alzheimer’s Disease Neuroimaging Initiative   +9 more
doaj   +1 more source