Results 121 to 130 of about 8,084,139 (305)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

TDTAC: a generalized time-dependent torsion angle correlation framework for resolving directional coordination in large biomolecular assemblies

Frontiers in Molecular Biosciences
Proteins function through coordinated, time-dependent conformational motions, yet conventional analyses often obscure how these dynamics propagate across complex assemblies. Here, we introduce a generalized Time-Dependent Torsion Angle Correlation (TDTAC)
Carolina Escobar Palacio, Tongye Shen, Chia-En A. Chang   +2 more
doaj   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Making the Complete OpenAIRE Citation Graph Easily Accessible Through Compact Data Representation

Journal of Open Humanities Data
The OpenAIRE graph contains a large citation graph dataset, with over 200 million publications and over two billion citations. The current graph is available as a dump with metadata which, when uncompressed, totals ∼2.5 TB.
Joakim Skarding, Pavel Sanda
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source

CLUSTERING BASED ON BETWEENNESS CENTRALITY IN PERIOD: TRANSFORMATION OF CORRELATION COEFFICIENT VALUE INTO DISTANCE IN MATRIC SPACE

Barekeng
The main information of this research is the transformation of the correlation coefficient value for stock price into the distance. It is done to create a representation in metric space that can be used in cluster analysis on the correlation network ...
Mokhammad Ridwan Yudhanegara, Edwin Setiawan Nugraha, Sisilia Sylviani, Karunia Eka Lestari, Ebenezer Bonyah   +4 more
doaj   +1 more source

Improving Dynamic Network Visualization via Geographic Mapping and Overlap Resolution [PDF]

openQuesta tesi descrive i metodi e le tecniche utilizzate per sviluppare integrazioni di visualizzazione di reti geospaziali in Collaboration Spotting X (CSX), uno strumento gratuito e open-source per la visualizzazione di dati basati su reti. Il nucleo
SADIN, AHMAD
core  

Dynamic Control of Isolated Network Microgrids: A Resilient Backpropagation Neural Network-Based Virtual Inertia Control Approach

In isolated networked microgrid with high penetration of solar and wind-based generation, maintaining system stability and achieving optimal dynamic performance poses significant challenges due to reduced mechanical inertia traditionally provided by ...
Hossain, Md Alamgir, Yang, Fuwen, Shobug, Md Asaduzzaman, Lu, Junwei   +3 more
core   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Note - The European Network for Dynamic Microsimulation (EURODYM) – A vision and the state of affairs [PDF]

This paper presents plans to initiate a European network for dynamic microsimulation, one of whose tasks will be to facilitate and stimulate exchange of research ideas and researchers.
Gijs Dekkers, Asghar Zaidi
core