Results 81 to 90 of about 553,239 (282)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Depth Prediction Improvement for Near-Field iToF Lidar in Low-Speed Motion State

Sensors
Current deep learning-based phase unwrapping techniques for iToF Lidar sensors focus mainly on static indoor scenarios, ignoring motion blur in dynamic outdoor scenarios.
Mena Nagiub, Thorsten Beuth, Ganesh Sistu, Heinrich Gotzig, Ciarán Eising   +4 more
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Foregrounds for observations of the cosmological 21 cm line: II. Westerbork observations of the fields around 3C196 and the North Celestial Pole

, 2009
In the coming years a new insight into galaxy formation and the thermal history of the Universe is expected to come from the detection of the highly redshifted cosmological 21 cm line.
Bernardi, G., Brentjens, M. A., Ciardi, B., de Bruyn, A. G., Harker, G., Jelić, V., Koopmans, L. V. E., Labropoulos, P., Offringa, A., Pandey, V. N., Schaye, J., Thomas, R. M., Yatawatta, S., Zaroubi, S.   +13 more
core   +2 more sources

Temporal Pyramid Alignment and Adaptive Fusion of Event Stream and Image Frame for Keypoint Detection and Tracking in Autonomous Driving

Alexandria Engineering Journal
This paper proposes a method to address the alignment and fusion challenges in multimodal fusion between event and RGB cameras. For multimodal alignment, we adopt the Temporal Pyramid Alignment mechanism to achieve multi-scale temporal synchronization of
Peijun Shi, Chee-Onn Chow, Wei Ru Wong
doaj   +1 more source

Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher, Charles B. Malpas, Stuart J. McDonald, William T. O’Brien, Craig Despott, Kelly L. Bertram, Matthew P. Pase, Lukas Frontzkowski, Meng Law, Terence J. O’Brien, Lucy Vivash   +10 more
wiley   +1 more source

The Impact of Road Traffic Noise on Housing Prices – Case Study in Poland

Real Estate Management and Valuation, 2020
Noise as a form of environmental pollution negatively affects the attractiveness of residential areas. Its adverse effect is particularly noticeable in the vicinity of roads with high traffic volume.
Szopińska Kinga, Krajewska Małgorzata, Kwiecień Janusz   +2 more
doaj   +1 more source

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

RMF: one-step radio map reconstruction via mean flow matching

Connection Science
Accurate radio map construction is essential for 6 G wireless network optimization, yet faces significant challenges due to sparse real-world measurements and dynamic environmental obstacles.
You Fu, Ruyun Fu, Shengliang Fang, Youchen Fan   +3 more
doaj   +1 more source

Efficacy of Intermittent Theta‐Burst Stimulation for Prolonged Disorders of Consciousness: A Prospective, Randomized, Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Emerging evidence suggests that low‐frequency neural oscillations are dynamically regulated by consciousness levels, with the recovery of low cortical activity potentially serving as a neurophysiological substrate for conscious emergence. Targeted enhancement of these low‐frequency rhythms in patients with disorders of consciousness
Chuan Xu, Jun Hu, Qianqian Wu, Min Wu, Yamei Yu, Hangcheng Li, Jian Gao, Jingqi Li, Nai Ding, Jie Yu, Benyan Luo   +10 more
wiley   +1 more source