Results 111 to 120 of about 1,334,442 (301)
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
The Effect of Bank Leverage on Profitability: Focus on Strengthening the Credit System in the Iranian Banking System [PDF]
مطالعات مالی و بانکداری اسلامی, 2018 One of the key indicators in the banking sector is bank leverage. Bank leverage refers to how resources are used in the balance sheet to finance the assets. The quality of banking assets has a significant impact on lending in banks.
Mahshid Shahchera, Mahnaz Valizadeh
doaj
HABIT FORMATION AND PRECAUTIONARY SAVING: EVIDENCE FROM THE KOREAN HOUSEHOLD PANEL STUDIES [PDF]
We examined the evidence of precautionary saving and Constantinides (1990) type habit formation model by using the Korean Household Panel Studies, which has six years of time series observations and thousands of cross section observations.
Wooheon Rhee
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Economic Distance and Regional Economic Growth in Iran [PDF]
پژوهشهای اقتصادی, 2015 The economic distance refers to the ease or difficulty for goods, services, labor, capital, information, and ideas to traverse space. This variable affects the regional economic growth through influencing location of firms, knowledge spillover and market
zahra dehghan shabani, Nematollah Akbari
doaj
The Impact of Country Risk Management on Economic Growth in the Selected OIC Countries
برنامهریزی و بودجه, 2021 The economic performance to reduce country risk, in which the existing economic, social, and political conditions negatively affect the capacity to repay foreign debt and attract foreign direct investment, is one of the prominent issues in economic ...
Farzam Sajjadieh Khajaviee +2 more
doaj
Identification and Estimation of Nonlinear Dynamic Panel Data Models with Unobserved Covariates [PDF]
This paper considers nonparametric identification of nonlinear dynamic models for panel data with unobserved voariates. Including such unobserved covariates may control for both the individual-specific unobserved heterogeneity and the endogeneity of the ...
Ji-Liang Shiu, Yingyao Hu
core
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Detection of Structural Breaks in Linear Dynamic Panel Data Models [PDF]
This paper develops a break detection procedure for the well-known AR(p) linear panel data model with exogenous or pre-determined regressors. The test allows for a structural break in the slope parameters as well as in the fixed effects.
Elias Tzavalis, Stefan de Wachter
core
SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1
FEBS Open Bio, EarlyView.Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl +13 more
wiley +1 more source