Results 101 to 110 of about 10,716,551 (348)
From Dynamic Programming to Bynamic Programming
Journal of Mathematical Analysis and Applications, 1993 The author suggests a new sequential optimization method called `bynamic programming', which includes dynamic programming as a special case. The objective function \(g(x,.)\) defined on \(X\times R^{\ell}\) is separable and at the same time nonincreasing or nondecreasing in the second variable for \(x\in X^ -\), \(x\in X^ +\) respectively, where \(X ...
openaire +2 more sources
Verification theorem and construction of epsilon-optimal controls for control of abstract evolution equations [PDF]
We study several aspects of the dynamic programming approach to optimal control of abstract evolution equations, including a class of semilinear partial differential equations.
Fabbri, Giorgio +2 more
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Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
A Note on a Rapid Grid Search Method for Solving Dynamic Programming Problems in Economics [PDF]
We introduce a rapid grid search method in solving the dynamic programming problems in economics. Compared to mainstream grid search methods, by using local information of the Bellman equation, this method can significantly increase the efficiency in ...
Hao Zhang, Hui He
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Taxation under Uncertainty – Problems of Dynamic Programming and Contingent Claims Analysis in Real Option Theory [PDF]
This article deals with the integration of taxes into real option-based investment models under risk neutrality and risk averison. It compares the possible approaches dynamic programming and contingent claims analysis to analyze their effects on the ...
Caren Sureth, Rainer Niemann
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
An analytical bound on the fleet size in vehicle routing problems: A dynamic programming approach [PDF]
, 2020 Ali Eshragh +2 more
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