Results 101 to 110 of about 9,287,091 (298)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Robot-assisted high-dynamic-range optical measurement

This paper presents a robot-assisted optical metrology system for measuring three-dimensional (3D) objects. The metrology system performs high-dynamic-range stitching measurements and incorporates self-calibration capabilities to correct systematic ...
Donglei Liu (713824), Samanta Piano (17491401), Shaojian Zhang (14196750), Helia Hooshmand (17683167), Samuel Liu (17172754), Xin Liu (17464212)   +5 more
core   +4 more sources

Expanded Performance Comparison of the Oncuria 10-Plex Bladder Cancer Urine Assay Using Three Different Luminex xMAP Instruments

Diagnostics
Background/Objectives: The clinically validated multiplex Oncuria bladder cancer (BC) assay quickly and noninvasively identifies disease risk and tracks treatment success by simultaneously profiling 10 protein biomarkers in voided urine samples.
Sunao Tanaka, Takuto Shimizu, Ian Pagano, Wayne Hogrefe, Sherry Dunbar, Charles J. Rosser, Hideki Furuya   +6 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Dynamic range analysis on MIMO-OFDM broadband channels in a populated time-varying indoor environment [PDF]

, 2007
We investigate the variations on channel capacity for a multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) system due to the presence of pedestrians.
Ziri-Castro, Karla, Suzuki, Hajime, Jishu Das Gupta, Hajime Suzuki, Karla Ziri-Castro, Ziri-Castro, Karla I., Das Gupta, Jishu   +6 more
core   +1 more source

High-Density Microfluidic Chip with Vertical Structure for Digital PCR

Sensors
Digital PCR, as a nucleic acid absolute quantification method at the single-molecule level, has been widely applied in early cancer screening, single-cell analysis, and other biomedical fields. However, existing digital PCR methods still suffer from high
Peng Sun, Huaqing Si, Gangwei Xu, Dongping Wu   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Evaluating harmonic and intermodulation distortion of mixed signals processed with dynamic range compression [PDF]

, 2014
Dynamic range compression of simple signals results in harmonic nonlinear distortion. However, for summed signals, predominantly inharmonic intermodulation distortion (IMD) is generated.
Toulson, R., Campbell, W., Paterson, J.
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Wide Dynamic Range CMOS Potentiostat for Amperometric Chemical Sensor

Sensors, 2010
Presented is a single-ended potentiostat topology with a new interface connection between sensor electrodes and potentiostat circuit to avoid deviation of cell voltage and linearly convert the cell current into voltage signal.
Wei-Song Wang, Wei-Ting Kuo, Hong-Yi Huang, Ching-Hsing Luo   +3 more
doaj   +1 more source