Results 101 to 110 of about 4,508,624 (301)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Towards Robustness in Residue Number Systems

, 2016
The problem of robustly reconstructing a large number from its erroneous remainders with respect to several moduli, namely the robust remaindering problem, may occur in many applications including phase unwrapping, frequency detection from several ...
Huo, Haiye, Xia, Xiang-Gen, Xiao, Li
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

DR Loss-Free Dithering-Based Digital Background Linearity Calibration for SAR-Assisted Multi-Stage ADCs With Digital Input-Interference Cancellation

IEEE Open Journal of Circuits and Systems
In this paper, we propose a correlation-based background linearity calibration technique to digitally correct the bit weights in successive approximation register (SAR)-assisted analog-to-digital converters (ADCs).
Lizhen Zhang, Bo Gao, Kun-Woo Park, Kent Edrian Lozada, Raymond Mabilangan, Hyeongjin Kim, Jianhui Wu, Seung-Tak Ryu   +7 more
doaj   +1 more source

Wide-Range Tunable Dynamic Property of Carbon Nanotube-Based Fibers

, 2015
Carbon nanotube (CNT) fiber is formed by assembling millions of individual tubes. The assembly feature provides the fiber with rich interface structures and thus various ways of energy dissipation, as reflected by the non-zero loss tangent (>0.028--0.045)
Li, QW(李清文), Pan, ZJ, Zhang, XH (郑新河), Zhang, XH(张骁华), Zhao, JN(赵静娜)   +4 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Predicting criticality and dynamic range in complex networks: effects of topology

, 2010
The collective dynamics of a network of coupled excitable systems in response to an external stimulus depends on the topology of the connections in the network.
Daniel B. Larremore, J. M. Beggs, Juan G. Restrepo, P. Erdős, R. T. Gray, Woodrow L. Shew   +5 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Companding technique for high dynamic range measurements using gafchromic films

, 2011
We propose a methodology to perform dose measurements using gafchromic films which can span several decades of dose levels. The technique is based on a rescaling approach using different films irradiated at different dose levels.
Battum, Childress, Coleman, Defraene, Dolby, Durante, Frank Van den Heuvel, Georg, Gilles Defraene, Micke, Smith, Williamson, Wouter Crijns, Zhu   +13 more
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source