Results 141 to 150 of about 1,370,654 (308)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Dynamic Response of Concrete Pavements under Vehicular Loads
, 2006 Considerable knowledge of pavement behaviour under static loads is available world-wide. The behaviour of concrete pavements under dynamic loads, however, has not received much attention and hence is not well understood at present.
Y. Darestani, Mostafa +3 more
core
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Shaking Table Tests of Steel Beam-Columns under Biaxial Bending
, 1990 application/pdfIn the course of the structural design, the dynamic response analysis is usually performed for the planer frames, separated from the prototype three-dimensional frame.
Yoshimura, Yukitoshi +4 more
core
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Dynamic agricultural supply response under economic transformation [PDF]
China has experienced dramatic economic transformation and is facing the challenge of ensuring steady agricultural growth. This study examines the crop sector by estimating the supply response for major crops in Henan province from 1998 to 2007. We use a
You, Liangzhi, Liu, Fengwei, Yu, Bingxin
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Steel Lattice Sightseeing Tower’s Horizontal Vibrations Induced by Human Movement
Researchers mostly concentrate on modelling walking induced dynamic loading on the light-weight structures like pedestrian bridges, grandstands or slender floor slabs.
Gaile, Līga, Radiņš, Ivars
core +1 more source
Three-dimensional dynamic response of infinite plate resting on multilayered orthotropic foundation under moving loads. [PDF]
PLoS OneZhang CL, Cao M, Hong L, Qi YF.
europepmc +1 more source