Results 121 to 130 of about 9,329,709 (259)
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Study on Drill String Fatigue Life in Deepwater Drilling
Shiyou jixie, 2016 Dynamic response of the deepwater drilling platform increases alternating loads of the drilling string.As a consequence,the calculation of drill string fatigue life becomes more complicated.By using the numerical simulation method,a method for studying ...
Wang Jiajia, Chen Jianmin
doaj
Applied SciencesBlast-induced vibrations from newly constructed tunnels may adversely affect adjacent existing tunnel structures. To ensure the safety of the existing tunnel, it is essential to investigate its dynamic response under blast disturbances.
Youxin Shao +5 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Applied SciencesPumped-storage power stations (PSPSs) are vital for grid stability, yet pump-turbines (PTs) operating in the S-shaped region often induce severe hydraulic instability.
Yutong Mao +4 more
doaj +1 more source
Dynamic response of corrugated steel culverts for railway lines
, 2020 Corrugated steel culverts are sometimes used as an alternative to portal frame bridges for small and medium crossings under railway lines. From a static point of view, the corrugated steel culverts are rather flexible structures and the load capacity ...
Karoumi, Raid,, Andersson, Andreas,
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Journal of Asian Architecture and Building EngineeringCombined with the validations of the nonlinear material models, this study addresses the nonlinear dynamic response, damage mechanisms and failure modes of reinforced concrete frame structures under rockfall impacts, utilizing explicit dynamic analysis ...
Tao Tian, Wengao Lu, Haoran Wang
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source