Results 111 to 120 of about 3,958,786 (306)

Dynamic Response and Lubrication Performance of Spur Gear Pair Under Time-Varying Rotation Speeds

Lubricants
The rotation speed directly influences the vibration and lubrication behaviors of gear pairs, but studying the effects of time-varying rotation speeds during their operation poses substantial challenges. The present work proposed an approach to analyzing
Jiaxing Pei, Yuanyuan Tian, Hongjuan Hou, Yourui Tao, Miaojie Wu, Zhigang Guan   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Study on Dynamic Response of Pile Foundation in Elastoplastic Soil Under Horizontal Loads

Buildings
The elastoplastic model can more accurately simulate the elastoplastic behavior of soil in the process of loading, so as to determine the soil resistance more accurately, which holds great significance in calculating the bearing capacity of pile ...
Xiaoqing Gu, Jiaqing Shu, Yuxuan Wang, Pengpeng Wang, Mingxing Zhu   +4 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Vibration Reduction Performance of a Novel Harmonic Frequency Damping Device for Damping Pad Floating Slab Track

Buildings
The stability of the damping pad floating slab track (DPFST) plays a critical role in the operational safety and passenger comfort of urban rail transit systems and represents a significant technical challenge.
Zhaowei Chen, Hanbo Zhang, Qianhua Pu, Pengfei Xu, Zhihui Chen   +4 more
doaj   +1 more source

Mathematical model for predicting human vertebral fracture [PDF]

, 1973
Mathematical model has been constructed to predict dynamic response of tapered, curved beam columns in as much as human spine closely resembles this form. Model takes into consideration effects of impact force, mass distribution, and material properties.
Benedict, J. V.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Seismic Response Analysis of Concrete Box-Type Subgrade in High-Speed Railways

Applied Sciences
China is prone to frequent earthquakes, impacting both the construction and operation of high-speed railways. The seismic response analysis is essential for the promotion and structural optimization of novel box-type subgrade structures.
Ying-Ying Chen, Hong Xiao, Xu-Guo Song, Shuai-Jie Guo, Bei-Er Luo, Mahantesh M. Nadakatti   +5 more
doaj   +1 more source

Wind loads on flat plate photovoltaic array fields (nonsteady winds) [PDF]

Techniques to predict the dynamic response and the structural dynamic loads of flat plate photovoltaic arrays due to wind turbulence were analyzed. Guidelines for use in predicting the turbulent portion of the wind loading on future similar arrays are ...
Miller, R. D., Zimmerman, D. K.
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source