Results 91 to 100 of about 3,958,786 (306)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Stability Analysis of Grid-Strengthening Geared Direct Grid-Connected Dual-Speed Slip-Synchronous Wind Turbines

IEEE Open Journal of Industry Applications
With the recent proliferation in penetration levels of converter-based grid-connected wind turbine systems, a decrease in grid strength has been observed.
Ryno Gerber, Maarten Jan Kamper
doaj   +1 more source

An earthquake response spectrum method for linear light secondary substructures [PDF]

, 2007
YesEarthquake response spectrum is the most popular tool in the seismic analysis and design of structures. In the case of combined primary-secondary (P-S) systems, the response of the supporting P substructure is generally evaluated without considering
Muscolino, G., Palmeri, Alessandro
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

A new forward‐flyback converter without right half plane zero

IET Power Electronics
Due to its unique features, the flyback converter is widely used to convert DC to DC power. This converter has a non‐minimum phase (NMP) dynamic behavior, which is one of its most significant disadvantages.
Sayed Mohsen Ahmadi, Navid Reza Abjadi, Sayed Vahid Mirmoghtadaei, Ehsan Adib   +3 more
doaj   +1 more source

Analysis of Dynamic Responses of Floating Offshore Wind Turbines in Typical Upstream Wake Conditions Based on an Innovative Coupled Dynamic Analysis Method

Journal of Marine Science and Engineering
Floating offshore wind turbines (FOWTs) are crucial for harnessing deep-sea wind energy resources. However, existing studies on FOWTs have predominantly focused on standalone wind turbines, neglecting the wake effects from upstream turbines within the ...
Yangwei Wang, Jisen Zong, Jianhui Mou, Junjie Yang, Xinghao Zhu   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Analysis of Mechanical Characteristics and Operation Risk of Synchronous Condenser Rotor Under Dynamic Conditions With Typical Fault

IET Electric Power Applications
To address the safety concerns regarding the mechanical performance of the rotor, a coupled electromagnetic–structural–fatigue simulation model is established to investigate the impact of transient shock processes under rotor interturn short circuit ...
Minghan Ma, Hao Wang, Yucai Wu, Xinkai Zhu   +3 more
doaj   +1 more source

Hydrodynamic Performance and Motion Response of a Novel Deep-Water TLP Floating Offshore Wind Turbine

Journal of Marine Science and Engineering
The deployment of floating offshore wind turbines (FOWTs) in deep, typhoon-prone waters like the South China Sea requires platforms with exceptional stability.
Ronghua Zhu, Zongyuan Lai, Chunlong Li, Haiping Qian, Huaqi Yuan, Yingchun Xie, Ke Sun   +6 more
doaj   +1 more source