Results 91 to 100 of about 1,167,602 (264)

Forced vibration of an axially functionally graded energy pile embedded in temperature-sensitive Winkler soils

Frontiers in Materials
In this study, forced vibration analysis of an energy pile with non-uniformity in vertically inhomogeneous soil is presented considering the non-uniform distributed temperature.
Zhuanzhuan Zhang, Zhao Lu, Zhao Lu
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Simulation Analysis of Seismic Response of Long-distance Suspended Pipeline

Shiyou jixie, 2017
In order to study the dynamic response of the long-distance suspended pipeline under the action of seismic load, the general finite element software ABAQUS has been used to conduct numerical simulation.
Lei Zhen, Liao Heng, Dong Feifei, Du Guofeng   +3 more
doaj  

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Numerical Analysis and Safety Assessment of Dynamic Response of Natural Gas Pipelines Under Vibration Loads from High-Speed Railway Tunnels

Applied Sciences
With the rapid expansion of high-speed railway (HSR) networks, the vibration impact on adjacent energy infrastructure has become a critical safety concern.
Meibao Chen, Zhengyu Yan, Xiaofei Jing, Jian Ou, Shangwei Wu, Tao Liu   +5 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Effect of Empty-Hole on Blasting-Induced Damage Evolution and Dynamic Response of Rock

Gaoya wuli xuebao
Aiming at the issue that traditional perimeter blasting easily induces random crack damage in surrounding rocks, this study conducts an in-depth analysis of the damage evolution laws and dynamic response characteristics in empty-hole directional blasting
Tao LI, Yu NI, Zhiliang WANG
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Study on Drill String Fatigue Life in Deepwater Drilling

Shiyou jixie, 2016
Dynamic response of the deepwater drilling platform increases alternating loads of the drilling string.As a consequence,the calculation of drill string fatigue life becomes more complicated.By using the numerical simulation method,a method for studying ...
Wang Jiajia, Chen Jianmin
doaj  

Response Characteristics and Safety Criterion of Double-Arch Tunnel Under Blast-Induced Disturbance from New Tunnel Excavation

Applied Sciences
Blast-induced vibrations from newly constructed tunnels may adversely affect adjacent existing tunnel structures. To ensure the safety of the existing tunnel, it is essential to investigate its dynamic response under blast disturbances.
Youxin Shao, Zhen Zhang, Jinshan Sun, Yingkang Yao, Nan Jiang, Shimao Ma   +5 more
doaj   +1 more source