Results 81 to 90 of about 1,167,602 (264)

Influence of Soil Plugging on Dynamic Soil Response During Simulated Pipe Pile Driving Model Test in Sands

Applied Sciences
The squeezing effect and strike-induced vibration generated by pile driving pose a threat to adjacent structures. To mitigate the squeezing effect, open-ended pipe piles were implemented. However, this type of pile brings a degree of soil-plugging effect,
Songchao Lin, Ye Lu, Chong Zhao
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Dynamic Response and Lubrication Performance of Spur Gear Pair Under Time-Varying Rotation Speeds

Lubricants
The rotation speed directly influences the vibration and lubrication behaviors of gear pairs, but studying the effects of time-varying rotation speeds during their operation poses substantial challenges. The present work proposed an approach to analyzing
Jiaxing Pei, Yuanyuan Tian, Hongjuan Hou, Yourui Tao, Miaojie Wu, Zhigang Guan   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Study on Dynamic Response of Pile Foundation in Elastoplastic Soil Under Horizontal Loads

Buildings
The elastoplastic model can more accurately simulate the elastoplastic behavior of soil in the process of loading, so as to determine the soil resistance more accurately, which holds great significance in calculating the bearing capacity of pile ...
Xiaoqing Gu, Jiaqing Shu, Yuxuan Wang, Pengpeng Wang, Mingxing Zhu   +4 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Vibration Reduction Performance of a Novel Harmonic Frequency Damping Device for Damping Pad Floating Slab Track

Buildings
The stability of the damping pad floating slab track (DPFST) plays a critical role in the operational safety and passenger comfort of urban rail transit systems and represents a significant technical challenge.
Zhaowei Chen, Hanbo Zhang, Qianhua Pu, Pengfei Xu, Zhihui Chen   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Seismic Response Analysis of Concrete Box-Type Subgrade in High-Speed Railways

Applied Sciences
China is prone to frequent earthquakes, impacting both the construction and operation of high-speed railways. The seismic response analysis is essential for the promotion and structural optimization of novel box-type subgrade structures.
Ying-Ying Chen, Hong Xiao, Xu-Guo Song, Shuai-Jie Guo, Bei-Er Luo, Mahantesh M. Nadakatti   +5 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source