Results 101 to 110 of about 1,370,654 (308)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Analysis of Stress Distribution Law and Dynamic Response of Deep Water Test String
Shiyou jixie, 2020 To study the stress distribution and the influence of internal pressure fluctuations on the dynamic response parameters of deep water test string under different working conditions, the calculation formulas of the axial force, axial stress, radial stress
Tang Xiandi +6 more
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Applied SciencesThe squeezing effect and strike-induced vibration generated by pile driving pose a threat to adjacent structures. To mitigate the squeezing effect, open-ended pipe piles were implemented. However, this type of pile brings a degree of soil-plugging effect,
Songchao Lin, Ye Lu, Chong Zhao
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Dynamic Response and Lubrication Performance of Spur Gear Pair Under Time-Varying Rotation Speeds
LubricantsThe rotation speed directly influences the vibration and lubrication behaviors of gear pairs, but studying the effects of time-varying rotation speeds during their operation poses substantial challenges. The present work proposed an approach to analyzing
Jiaxing Pei +5 more
doaj +1 more source
Dynamic response of shear thickening fluid under laser induced shock
, 2015 The dynamic response of the 57 vol./vol. % dense spherical silica particle-polyethylene glycol suspension at high pressure was investigated through short pulsed laser induced shock experiments.
Yin QY(殷秋运) +3 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Study on Dynamic Response of Pile Foundation in Elastoplastic Soil Under Horizontal Loads
BuildingsThe elastoplastic model can more accurately simulate the elastoplastic behavior of soil in the process of loading, so as to determine the soil resistance more accurately, which holds great significance in calculating the bearing capacity of pile ...
Xiaoqing Gu +4 more
doaj +1 more source