Results 71 to 80 of about 1,167,602 (264)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Analysis of Dynamic Responses of Floating Offshore Wind Turbines in Typical Upstream Wake Conditions Based on an Innovative Coupled Dynamic Analysis Method

Journal of Marine Science and Engineering
Floating offshore wind turbines (FOWTs) are crucial for harnessing deep-sea wind energy resources. However, existing studies on FOWTs have predominantly focused on standalone wind turbines, neglecting the wake effects from upstream turbines within the ...
Yangwei Wang, Jisen Zong, Jianhui Mou, Junjie Yang, Xinghao Zhu   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

A new forward‐flyback converter without right half plane zero

IET Power Electronics
Due to its unique features, the flyback converter is widely used to convert DC to DC power. This converter has a non‐minimum phase (NMP) dynamic behavior, which is one of its most significant disadvantages.
Sayed Mohsen Ahmadi, Navid Reza Abjadi, Sayed Vahid Mirmoghtadaei, Ehsan Adib   +3 more
doaj   +1 more source

Hydrodynamic Performance and Motion Response of a Novel Deep-Water TLP Floating Offshore Wind Turbine

Journal of Marine Science and Engineering
The deployment of floating offshore wind turbines (FOWTs) in deep, typhoon-prone waters like the South China Sea requires platforms with exceptional stability.
Ronghua Zhu, Zongyuan Lai, Chunlong Li, Haiping Qian, Huaqi Yuan, Yingchun Xie, Ke Sun   +6 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Analysis of Stress Distribution Law and Dynamic Response of Deep Water Test String

Shiyou jixie, 2020
To study the stress distribution and the influence of internal pressure fluctuations on the dynamic response parameters of deep water test string under different working conditions, the calculation formulas of the axial force, axial stress, radial stress
Tang Xiandi, Sun Qiaolei, Li Zhong, Feng Ding, Wang Erjun, Meng Wenbo, Yan Bangchuan   +6 more
doaj  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source