Results 71 to 80 of about 3,958,786 (306)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Measurement of Dynamic Response and Analysis of Characteristics of Heavy-Haul Railway Tunnel Bottom Structure Under Train Loading

Buildings
This study investigates the dynamic response characteristics of the tunnel bottom structure, focusing on a heavy-haul railway tunnel. To assess the condition of the tunnel bottom, geological radar and drilling core techniques were employed, along with on-
Dengke Wang, Jie Su, Furong Luo, Zhe Wang, Jiansheng Fan, Jianjun Luo, Guanqing Wang   +6 more
doaj   +1 more source

Assessing 20th century climate-vegetation feedbacks of land-use change and natural vegetation dynamics in a fully coupled vegetation-climate model [PDF]

, 2010
This study describes the coupling of the dynamic global vegetation model (DGVM), Lund–Potsdam–Jena Model for managed land (LPJmL), with the general circulation model (GCM), Simplified Parameterizations primitivE Equation DYnamics model (SPEEDY), to study
Avissar, Bala, Betts, Betts, Bonan, Bondeau, Boucher, Bounoua, Bracco, Brovkin, Brovkin, Chase, Claussen, Collatz, Collatz, Cook, Costa, Cowling, Cox, Cox, Delire, Dickinson, Doherty, Farquhar, Feddema, Findell, Foley, Friedlingstein, Gallimore, Gedney, Gerten, Gerten, Gleckler, Govindasamy, Haarsma, Haarsma, Haarsma, Hagen, Hagen-Zanker, Hagen-Zanker, Hazeleger, Jahn, Jones, Kleidon, Klein Goldewijk, Koster, Kucharski, Kucharski, Kucharski, Levis, Lotze-Campen, Loveland, Lucht, Mabuchi, Marland, Matthews, Matthews, Maynard, Maynard, Molteni, Myhre, Müller, Müller, Notaro, Notaro, Notaro, O'Ishi, Opsteegh, Oyama, Pielke, Pielke, Pitman, Ronda, Rost, Schaeffer, Scholze, Sitch, Solomon, Sterl, Strengers, Voldoire, Xie, Zhao   +82 more
core   +2 more sources

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Vibration of a Beam on a Pasternak Foundation Under the Action of Moving Loads

Журнал інженерних наук
The article is devoted to solving an essential applied problem in deformable solid mechanics. When using refined models for an elastic foundation, obtaining more accurate numerical results for practical applications is possible, albeit with increased ...
Yaniutin Y., Voropay A., Povaliaiev S., Sharapata A., Matviienko O.   +4 more
doaj   +1 more source

Immune response dynamics

Mathematical and Computer Modelling, 2011
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Burroughs, N. J., Oliveira, B. M. P. M., Pinto, A. A., Ferreira, Miguel   +3 more
openaire   +3 more sources

Research related to vibrations from high speed railway traffic

, 2008
We discuss here recent results from several research programmes related to dynamic aspects and vibrations induced by high speed railway traffic, developed at the computational mechanics group, within the “Escuela de Ingenieros de Caminos” of the ...
Gabaldón Castillo, Felipe, Goicolea Ruigómez, José María   +1 more
core  

Analysis of the dynamic response of multielement semiconductor lasers [PDF]

, 1985
We present a derivation of the dynamic response of a semiconductor laser consisting of more than one active element. We show that the amplitude and phase of the modulated cavity adiabatically follows the complex resonance of the composite cavity; and ...
Lang, Robert J., Yariv, Amnon
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Dynamic response solutions of unsaturated soil foundation using soil-water characteristic curve considering deformation effects

Yantu gongcheng xuebao
To investigate the dynamic response of unsaturated soils under moving loads, a new soil-water characteristic curve (SWCC) model is established considering the deformation caused by applied load based on the traditional V-G SWCC model. Using this modified
HU Jing 1 , JIN Linlian 1, LÜ Zhihao 1, ZHANG Jiakang 1, BIAN Xuecheng 2
doaj   +1 more source