Results 51 to 60 of about 1,167,602 (264)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Challenges in Risk Analysis and Assessment of the Railway Transport Vibration on Buildings

Applied Sciences
Traffic-induced vibrations from road and rail systems pose a significant threat to the structural integrity and operational safety of buildings, especially masonry structures located near planned infrastructure such as tunnels.
Filip Pachla, Tadeusz Tatara, Waseem Aldabbik   +2 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Experimental study on dynamic characteristics and energy dissipation of weakly cemented rock-like materials

Frontiers in Materials
The structural stability of coal seam roof rock mass under dynamic load in engineering practice is directly influenced by the dynamic characteristics of weakly consolidated coal measures rock.
Guodong Shi, Duoxi Yao, Jiehao Wu, Jiehao Wu, Fangyi Meng   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Dynamic Characteristics and Parametric Sensitivity Analysis of Underground Powerhouse in Pumped Storage Power Stations

Applied Sciences
China has witnessed extensive construction of underground powerhouses for pumped storage power stations. With the continuous increase in unit capacity, vibration problems have become particularly pronounced.
Junhao Gao, Zhenzhong Shen, Yiqing Sun, Lei Gan, Liqun Xu, Hongwei Zhang, Yaxin Feng, Yong Ni, Yanhe Zhang, Yang Xiang   +9 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Dynamic response of gear fault diagnosis based on dynamic transmission error

Jixie chuandong
ObjectiveIn response to the current lack of a unified modeling and stiffness solving method for multiple fault types, as well as the inability to perform comparative analysis across multiple faults, a unified modeling and stiffness solving approach was ...
YI Wenhao, MENG Fanshan, ZHANG Xin, JIN Yulin, WANG Jiaxu   +4 more
doaj  

Measurement of Dynamic Response and Analysis of Characteristics of Heavy-Haul Railway Tunnel Bottom Structure Under Train Loading

Buildings
This study investigates the dynamic response characteristics of the tunnel bottom structure, focusing on a heavy-haul railway tunnel. To assess the condition of the tunnel bottom, geological radar and drilling core techniques were employed, along with on-
Dengke Wang, Jie Su, Furong Luo, Zhe Wang, Jiansheng Fan, Jianjun Luo, Guanqing Wang   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source