Results 61 to 70 of about 1,167,602 (264)

Vibration of a Beam on a Pasternak Foundation Under the Action of Moving Loads

Журнал інженерних наук
The article is devoted to solving an essential applied problem in deformable solid mechanics. When using refined models for an elastic foundation, obtaining more accurate numerical results for practical applications is possible, albeit with increased ...
Yaniutin Y., Voropay A., Povaliaiev S., Sharapata A., Matviienko O.   +4 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Dynamic response solutions of unsaturated soil foundation using soil-water characteristic curve considering deformation effects

Yantu gongcheng xuebao
To investigate the dynamic response of unsaturated soils under moving loads, a new soil-water characteristic curve (SWCC) model is established considering the deformation caused by applied load based on the traditional V-G SWCC model. Using this modified
HU Jing 1 , JIN Linlian 1, LÜ Zhihao 1, ZHANG Jiakang 1, BIAN Xuecheng 2
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dynamic response characteristics of the initial support structure of the double-track tunnel blasting

Shenzhen Daxue xuebao. Ligong ban
In the process of blasting excavation of the later excavated tunnel, it is crucial to ensure the safety of blasting vibration in the first excavated tunnel.
HUANG Chuansheng, YANG Xin, LIN Jihua, XU Hao, HU Deyu, REN Kaifu   +5 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Stability Analysis of Grid-Strengthening Geared Direct Grid-Connected Dual-Speed Slip-Synchronous Wind Turbines

IEEE Open Journal of Industry Applications
With the recent proliferation in penetration levels of converter-based grid-connected wind turbine systems, a decrease in grid strength has been observed.
Ryno Gerber, Maarten Jan Kamper
doaj   +1 more source