Results 61 to 70 of about 9,329,709 (259)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Applied SciencesChina has witnessed extensive construction of underground powerhouses for pumped storage power stations. With the continuous increase in unit capacity, vibration problems have become particularly pronounced.
Junhao Gao +9 more
doaj +1 more source
Parameter sensitivity study of dynamic response for jack-ups by FEM analysis
, 2016 Jack-up platforms will generally behave as highly dynamic systems because of the structure flexibility. The environmental forces acting on these jack-ups will therefore induce significant dynamic response.
Nie, Wenjun +6 more
core
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Oscillations of First Order Delay Dynamic Equations
, 2006 Stavroulakis, Ioannis/0000-0002-4810-0540Consider the first order linear delay dynamic equation of the forms x(Delta)(t) + p(t)x(tau(t)) = 0. (E) New oscillation criteria are established which contain well-known criteria for delay differential and ...
Sahiner, Y., Stavroulakis, I. P.
core +1 more source
Dynamic response of gear fault diagnosis based on dynamic transmission error
Jixie chuandongObjectiveIn response to the current lack of a unified modeling and stiffness solving method for multiple fault types, as well as the inability to perform comparative analysis across multiple faults, a unified modeling and stiffness solving approach was ...
YI Wenhao +4 more
doaj
BuildingsThis study investigates the dynamic response characteristics of the tunnel bottom structure, focusing on a heavy-haul railway tunnel. To assess the condition of the tunnel bottom, geological radar and drilling core techniques were employed, along with on-
Dengke Wang +6 more
doaj +1 more source
A BIO-ECONOMIC DYNAMIC PROGRAMMING ANALYSIS OF THE SEASONAL SUPPLY RESPONSE BY FLORIDA DAIRY PRODUCERS [PDF]
Seasonal price premiums have been proposed as a means of dampening the highly seasonal patterns of milk production in Florida. A Markov decision bio-economic model of the breeding and replacement decisions was solved via stochastic dynamic programming ...
Delorenzo, Michael A. +2 more
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Vibration of a Beam on a Pasternak Foundation Under the Action of Moving Loads
Журнал інженерних наукThe article is devoted to solving an essential applied problem in deformable solid mechanics. When using refined models for an elastic foundation, obtaining more accurate numerical results for practical applications is possible, albeit with increased ...
Yaniutin Y. +4 more
doaj +1 more source