Results 31 to 40 of about 8,893,345 (301)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Dynamic Responses of U-Shaped Caverns under Transient Stress Waves in Deep Rock Engineering

open access: yesMathematics
Deep caverns are frequently subjected to transient loading, resulting in different failure characteristics in the surrounding rock compared to those in shallow caverns.
Lisha Liang   +3 more
doaj   +1 more source

Slamming induced dynamic response of a floating structure

open access: yes, 2012
Study of the slamming phenomenon is one of the most important branches of the floating structure dynamics. Experimental study of the floating structure dynamics can be very expensive because it requires a long wave flume and a moving model.
Lotfollahi-Yaghin, Mohammad Ali   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Social Response and Measles Dynamics

open access: yesStats, 2023
Measles remains one of the leading causes of death among young children globally, even though a safe and cost-effective vaccine is available. Vaccine hesitancy and social response to vaccination continue to undermine efforts to eradicate measles. In this study, we consider data about measles vaccination and measles prevalence in Germany for the years ...
Atinuke O. Adebanji   +5 more
openaire   +3 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Dynamics behavior analysis of spatial parallel coordinate measuring mechanism with spherical clearance joints

open access: yesMechanics & Industry
A universal dynamics modeling and analysis method applied for spatial parallel coordinate measuring mechanism (SPCMM) is proposed. The influence of spherical clearance joints on the accuracy of SPCMM cannot be ignored, it is necessary to study the ...
Sheng Yongchao, Chen Xiulong
doaj   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

The development of a dynamic amplification estimator for bridges with good road profiles [PDF]

open access: yes, 2006
The paper considers the influence of the surface profile on the dynamic amplification of a simply supported bridge when subject to a quarter car vehicle model.
O'Brien, Eugene J.   +2 more
core   +1 more source

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