Results 151 to 160 of about 278 (215)

Mammalian Proteome Profiling Reveals Readers and Antireaders of Strand‐Symmetric and ‐Asymmetric 5‐Hydroxymethylcytosine‐Modifications in DNA

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
We investigate by proteomics studies how strand‐symmetric and ‐asymmetric cytosine 5‐modifications in DNA are selectively recognized by the nuclear proteome. Using promoter probes with defined modification patterns, we identify tissue‐specific reader proteinsincluding MYC, MAX, and RFX5that discriminate 5‐hydroxymethylcytosine symmetry and sequence ...
Lena Engelhard   +8 more
wiley   +1 more source

Spectral Decomposition of Chemical Semantics for Activity Cliffs‐Aware Molecular Property Prediction

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
PrismNet mimics chemical intuition by functioning as a computational prism, refracting molecular graphs into complementary semantic views and spectral frequencies. This dual‐decomposition strategy effectively captures both global topologies and subtle “activity cliff” perturbations.
Chaoyang Xie   +9 more
wiley   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong   +11 more
wiley   +1 more source

E2EE enhanced patient-centric blockchain-based system for EHR management. [PDF]

open access: yesPLoS One
Haddad A   +5 more
europepmc   +1 more source

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

open access: yesAdvanced Science, Volume 13, Issue 16, 18 March 2026.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He   +5 more
wiley   +1 more source

Crater Observing Bioinspired Rolling Articulator (COBRA)

open access: yesAdvanced Intelligent Systems, Volume 8, Issue 3, March 2026.
Crater Observing Bio‐inspired Rolling Articulator (COBRA) is a modular, snake‐inspired robot that addresses the mobility challenges of extraterrestrial exploration sites such as Shackleton Crater. Incorporating snake‐like gaits and tumbling locomotion, COBRA navigates both uneven surfaces and steep crater walls.
Adarsh Salagame   +4 more
wiley   +1 more source

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