Results 101 to 110 of about 226,897 (274)

Inferring Gene Regulatory Networks From Single‐Cell RNA Sequencing Data by Dual‐Role Graph Contrastive Learning

Advanced Science, EarlyView.
RegGAIN is a novel and powerful deep learning framework for inferring gene regulatory networks (GRNs) from single‐cell RNA sequencing data. By integrating self‐supervised contrastive learning with dual‐role gene representations, it consistently outperforms existing methods in both accuracy and robustness.
Qiyuan Guan, Jiating Yu, Jieyi Pan, Fan Yuan, Jiadong Ji, Rusong Zhao, Zhi‐Ping Liu, Bingqiang Liu, Ling‐Yun Wu, Duanchen Sun   +9 more
wiley   +1 more source

A Study of the Effect of Temperature on the Capacitance Characteristics of a Metal-μhemisphere Resonant Gyroscope

Sensors
Metal-μhemispherical resonant gyros (M-μHRGs) are widely used in highly dynamic navigation systems in extreme environments due to their high accuracy and structural stability.
Xiangxian Yao, Hui Zhao, Zhong Su, Xibing Gu, Sirui Chu   +4 more
doaj   +1 more source

Dynamic Semantics as Monadic Computation [PDF]

, 2012
This paper proposes a formulation of the basic ideas of dynamic semantics in terms of the state monad. Such a monadic treatment allows to specify meanings as computations that clearly separate operations accessing and updating the context from purely truth conditional meaning composition.
openaire   +2 more sources

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Centering in Dynamic Semantics [PDF]

Proceedings of the 16th conference on Computational linguistics -, 1996
Centering theory posits a discourse center, a distinguished discourse entity that is the topic of a discourse. A simplified version of this theory is developed in a Dynamic Semantics framework. In the resulting system, the mechanism of center shift allows a simple, elegant analysis of a variety of phenomena involving sloppy identity in ellipsis and ...
openaire   +2 more sources

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Design and semantics of form and movement (DeSForM 2006) [PDF]

, 2006
Design and Semantics of Form and Movement (DeSForM) grew from applied research exploring emerging design methods and practices to support new generation product and interface design.
Feijs, Loe, Kyffin, Steven, Young, Robert   +2 more
core  

Machine Learning‐Guided Engineering of Protein Phase Separation Properties in Immune Regulation

Advanced Science, EarlyView.
PScalpel, a machine learning model integrating protein structure extraction, graph contrastive learning, and a genetic algorithm, guides the engineering of protein phase separation ability. It adopts transfer learning methods to provide predictive recommendations for protein phase separation ability changes through single amino acid mutations in a ...
Chenqiu Zhang, Jia Wang, Zhe Wang, Liyan Zhu, Sihui Cai, Luzhi Zhan, Haorui Liang, Yaoxing Wu, Jianqiang Li, Jun Cui   +9 more
wiley   +1 more source

Extended Dynamic Model for the UR16e 6-Degree-of-Freedom Robotic Manipulator

Sensors
This study develops and validates an Extended Analytical Dynamic Model (EADM) of the UR16e 6-Degree-of-Freedom (DoF) industrial robot, incorporating actuator dynamics and a friction model to address the lack of dynamic information provided by the ...
John Kern, Luis Donoso, Claudio Urrea, Guillermo González   +3 more
doaj   +1 more source

Automatically Defining Protein Words for Diverse Functional Predictions Based on Attention Analysis of a Protein Language Model

Advanced Science, EarlyView.
Understanding protein sequence–function relationships remains challenging due to poorly defined motifs and limited residue‐level annotations. An annotation‐agnostic framework is introduced that segments protein sequences into “protein words” using attention patterns from protein language models.
Hedi Chen, Jingrui Zhong, Xiaochun Zhang, Jingke Chen, Lin Guo, Xiaoliang Xiong, Xiaonan Zhang, Xiangyu Liu, Bailong Xiao, Boxue Tian   +9 more
wiley   +1 more source