Results 41 to 50 of about 638,996 (262)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

A Dynamic Fuzzy Cluster Algorithm for Time Series

Abstract and Applied Analysis, 2013
This paper presents an efficient algorithm, called dynamic fuzzy cluster (DFC), for dynamically clustering time series by introducing the definition of key point and improving FCM algorithm.
Min Ji, Fuding Xie, Yu Ping
doaj   +1 more source

Simulating Hamiltonian Dynamics with a Truncated Taylor Series

Physical Review Letters, 2015
We describe a simple, efficient method for simulating Hamiltonian dynamics on a quantum computer by approximating the truncated Taylor series of the evolution operator. Our method can simulate the time evolution of a wide variety of physical systems. As in another recent algorithm, the cost of our method depends only logarithmically on the inverse of ...
Berry, Dominic W., Childs, Andrew M., Cleve, Richard, Kothari, Robin, Somma, Rolando D.   +4 more
openaire   +6 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Novel Method for Estimating Time-Varying COVID-19 Transmission Rate

Mathematics, 2023
The transmission rate is an important indicator for characterizing a virus and estimating the risk of its outbreak in a certain area, but it is hard to measure. COVID-19, for instance, has greatly affected the world for more than 3 years since early 2020,
Hongfei Xiao, Deqin Lin, Shiyu Li
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Dynamic Multi-Scale Convolutional Neural Network for Time Series Classification

IEEE Access, 2020
Time series classification is an essential task in many real-world application domains. As a popular deep learning network, convolutional neural networks have achieved excellent performance in time series classification tasks.
Bin Qian, Yong Xiao, Zhenjing Zheng, Mi Zhou, Wanqing Zhuang, Sen Li, Qianli Ma   +6 more
doaj   +1 more source

Minimum Cost Averaging for Multivariate Time Series Using Constrained Dynamic Time Warping: A Case Study in Robotics

IEEE Access, 2023
In this paper, an innovative algorithm for averaging a set of multivariate time series with different lengths based on Constrained Dynamic Time Warping (CDTW) is proposed.
Irati Rasines, Anthony Remazeilles, Miguel Prada, Itziar Cabanes   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source